Impaired Cerebral Vasoreactivity Despite Symptom Resolution in Sports-Related Concussion
| Autor: | Tonia Sabo, Justin Frantz, Linda S. Hynan, Megan N. Murphy, Farzaneh A. Sorond, Sushmita Purkayastha, Kathleen R. Bell, Sydney H Lyng |
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| Rok vydání: | 2019 |
| Předmět: |
Male
030506 rehabilitation medicine.medical_specialty Traumatic brain injury Ultrasonography Doppler Transcranial Sport related concussion 03 medical and health sciences Young Adult 0302 clinical medicine Physical medicine and rehabilitation Medicine Dementia Humans Brain Concussion business.industry Neurodegeneration Hemodynamics Original Articles medicine.disease Return to play Increased risk Cerebral blood flow Athletes Cerebrovascular Circulation Athletic Injuries Female Neurology (clinical) 0305 other medical science business 030217 neurology & neurosurgery Blood Flow Velocity |
| Zdroj: | J Neurotrauma |
| ISSN: | 1557-9042 |
| Popis: | Traumatic brain injury (TBI) is associated with increased risk of later-life neurodegeneration and dementia. However, the underpinning mechanisms are poorly understood, and secondary injury resulting from perturbed physiological processes plays a significant role. Cerebral vasoreactivity (CVR), a measure of hemodynamic reserve, is known to be impaired in TBI. However, the temporal course of this physiological perturbation is not established. We examined CVR and clinical symptoms on day 3 (T1), day 21 (T2), and day 90 (T3) after concussion in collegiate athletes and cross-sectionally in non-injured controls. Changes in middle cerebral artery blood flow velocity (MCAV; transcranial Doppler ultrasonography) were measured during changes in end-tidal CO(2) (PetCO(2)) at normocapnia, hypercapnia (inspiring 8% CO(2)), and hypocapnia (hyperventilation). CVR was determined as the slope of the linear relationship and expressed as percent change in MCAV per mmHg change in PetCO(2). CVR was attenuated during the acute phase T1 (1.8 ± 0.4U; p = 0.0001), subacute phases T2 (2.0 ± 0.4U; p = 0.0017), and T3 (1.9 ± 0.6U; p = 0.023) post-concussion compared to the controls (2.3 ± 0.3U). Concussed athletes exhibited higher symptom number (2.5 ± 3.0 vs. 12.1 ± 7.0; p |
| Databáze: | OpenAIRE |
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