Bone marrow culture and haemopoietic growth factors: Recent developments and current status
| Autor: | Doris Hovgaard, Asbjørn Nymark Jensen, Søren Knudtzon, Børge Thing Mortensen |
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| Rok vydání: | 2009 |
| Předmět: |
Hematopoietic Cell Growth Factors
Clinical uses of mesenchymal stem cells Bone Marrow Cells Hematology General Medicine Biology Hematopoietic Stem Cells medicine.disease Colony-stimulating factor Leukemia Haematopoiesis medicine.anatomical_structure Bone Marrow Multipotent Stem Cell Cell culture Immunology medicine Humans Bone marrow Growth Substances Cells Cultured |
| Zdroj: | European Journal of Haematology. 42:77-83 |
| ISSN: | 1600-0609 0902-4441 |
| DOI: | 10.1111/j.1600-0609.1989.tb01241.x |
| Popis: | The use of semi-solid cultures of bone marrow cells is briefly reviewed. In the last two decades this technique has greatly improved our understanding of the hierarchical structure of cell production and its regulatory factors. It is now well established that relatively few multipotent stem cells, with self-renewing capacity, are feeding cells into the differentiating pool of all the different lineages of mature cells found in blood. The proliferation and differentiation in this system are controlled by specific haemopoeitic growth factors, which also regulate the function of the mature cells. Several of these factors are now produced in recombinant form, allowing further studies of their biological significance. Clinical trials with two of the factors have supported the experimental evidence for their in vivo function, and they can be administered without serious side effects. The clinical access to these factors is promising for future treatment of cancer patients and may possibly completely change the outcome of several haematological and infectious diseases. |
| Databáze: | OpenAIRE |
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