Comparison of the effects of intensive insulin treatment modalities on cardiovascular biomarkers in type 1 diabetes mellitus
| Autor: | Hayal Boyacioglu, Eser Sozmen Yildirim, Şevki Çetinkalp, Yasemin Delen, Candeger Yilmaz, Muammer Karadeniz, Canan Felekoglu |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Vascular Endothelial Growth Factor A Insulin pump medicine.medical_specialty Homocysteine Endocrinology Diabetes and Metabolism medicine.medical_treatment Fibrinogen Gastroenterology Injections Cohort Studies chemistry.chemical_compound Insulin Infusion Systems Internal medicine Diabetes mellitus Plasminogen Activator Inhibitor 1 Internal Medicine Humans Insulin Medicine Chemokine CCL2 Glycemic Type 1 diabetes business.industry General Medicine medicine.disease Lipoproteins LDL C-Reactive Protein Diabetes Mellitus Type 1 Endocrinology chemistry Cardiovascular Diseases Cohort Female business Biomarkers medicine.drug |
| Zdroj: | Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 9:157-162 |
| ISSN: | 1871-4021 |
| DOI: | 10.1016/j.dsx.2015.04.011 |
| Popis: | A B S T R A C T Aim: To evaluate effects of intensive insulin treatment modalities on cardiovascular biomarkers in patients with type 1 diabetes mellitus (T1DM). Materials and methods: A total of 25 patients with T1DM receiving intensive insulin therapy either in the form of continuous insulin pump (IP group; n = 13) or as multiple daily injections (MDI group; n = 12) and 13 controls (control group, n = 13) were included. Data on demographics, anthropometrics, diabetes history, and laboratory findings including glycemic and lipid parameters, and cardiovascular biomarkers [C-reactive protein (mg/dL), homocysteine (mmol/L), fibrinogen (mg/dL), oxidized LDL (ng/dL), PAI-1 (ng/mL), MCP-1 (pg/mL) and VEGF (pg/mL)] were recorded in each group. Correlation of cardiovascular biomarkers to other parameters was also evaluated in T1DM patients. Results: Apart from significantly higher mean (SD) values for HbA1c [6.1 (0.3) vs. 5.6 (0.5)% (43 (3) vs. 38 (5) mmol/mol), p < 0.05)] and HDL-cholesterol [71.5 (13.6) vs. 58.2 (10.8), p < 0.01) in the IP than in the MDI group, no significance difference was noted between insulin treatment modalities as well as between patient and control groups in terms of demographic, anthropometric and laboratory parameters. Negative correlation of MCP-1 to treatment duration (r = 0.615, p = 0.025), and HDL-c to CRP (r = 0.685, p = 0.010) and VEGF (r = 0.678, p = 0.011) was noted in IP group, whereas positive correlation of PAI-1 to diabetes age (r = 0.805, p = 0.002) and treatment duration was noted in MDI group. Conclusion: Our findings in a cohort of T1DM patients with optimal glycemic control revealed that intensive insulin therapy was not associated with an increase in atherosclerotic markers in T1DM, regardless of whether continuous IP infusion or MDIs was administered. 2015 Published by Elsevier Ltd on behalf of Diabetes India. |
| Databáze: | OpenAIRE |
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