Common genetic variants associated with cognitive performance identified using the proxy-phenotype method
| Autor: | Magnus Johannesson, André G. Uitterlinden, Cornelius A. Rietveld, Nicholas J. Timpson, Sarah E. Medland, Tõnu Esko, Beben Benyamin, Ian J. Deary, Sven J. van der Lee, Christiaan de Leeuw, Nicholas G. Martin, Matt McGue, Cornelia M. van Duijn, David C. Liewald, Patrick Turley, Nancy L. Pedersen, Paul Lichtenstein, Jaime Derringer, Frank C. Verhulst, James J. Lee, Carla A. Ibrahim-Verbaas, Dalton Conley, Philipp Koellinger, John M. Starr, Tune H. Pers, Christopher F. Chabris, David Cesarini, David Laibson, Edward L. Glaeser, Najaf Amin, Olga Rostapshova, Maciej Trzaskowski, Juha Karjalainen, Mary E. Ward, Caroline Hayward, Valur Emilsson, Patrik K. E. Magnusson, Henning Tiemeier, Daniel J. Benjamin, Robert Plomin, David J. Porteous, George Davey Smith, Michael B. Miller, Margaret J. Wright, Fernando Rivadeneira, Vincent W. V. Jaddoe, Anna A. E. Vinkhuyzen, William G. Iacono, Lude Franke, Peter M. Visscher, Rudolf S N Fehrmann, Gail Davies, Andrew D. Johnson, Steven Pinker, Riccardo E. Marioni, Blair H. Smith, George McMahon, Danielle Posthuma, Narelle K. Hansell |
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| Přispěvatelé: | Human genetics, NCA - Brain mechanisms in health and disease, Neuroscience Campus Amsterdam - Brain Mechanisms in Health & Disease, Functional Genomics, Complex Trait Genetics, Tinbergen Institute, Amsterdam Neuroscience - Complex Trait Genetics, Rietveld, Cornelius A, Esko, Tõnu, Davies, Gail, Pers, Tune H, Benyamin, Beben, Koellinger, Philipp D, Damage and Repair in Cancer Development and Cancer Treatment (DARE), Guided Treatment in Optimal Selected Cancer Patients (GUTS), Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Stem Cell Aging Leukemia and Lymphoma (SALL), Entrepreneurship & Innovation (ABS, FEB), Epidemiology, Erasmus MC other, Child and Adolescent Psychiatry / Psychology, Internal Medicine |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
Multifactorial Inheritance Cell Adhesion Molecules Neuronal LOCI Social Sciences Single-nucleotide polymorphism Genome-wide association study INTELLIGENCE Nerve Tissue Proteins Biology Polymorphism Single Nucleotide Synaptic Transmission Corrections Cognition Memory medicine ACADEMIC-ACHIEVEMENT Dementia GWAS Humans Learning Effects of sleep deprivation on cognitive performance GENOME-WIDE ASSOCIATION Neural Cell Adhesion Molecules Genetics Multidisciplinary Neuronal Plasticity proxy-phenotype method Memoria COMPONENTS Calcium-Binding Proteins medicine.disease Multiple comparisons problem Octamer Transcription Factors Female SDG 4 - Quality Education |
| Zdroj: | Proceedings of the National Academy of Sciences of the United States of America, 111(38), 13790-13794. National Academy of Sciences Proceedings of the National Academy of Sciences Rietveld, C A, Esko, T, Davies, G, Pers, T H, Turley, P, Benyamin, B, Chabris, C F, Emilsson, V, Johnson, A D, Lee, J J, de Leeuw, C A, Marioni, R E, Medland, S E, Miller, M B, Rostapshova, O, van der Lee, S J, Vinkhuyzen, A A, Amin, N, Conley, D, Derringer, J, van Duijn, C M, Fehrmann, R, Franke, L, Glaeser, E L, Hansell, N K, Hayward, C, Lacono, W G, Ibrahim-Verbaas, C A, Jaddoe, V, Karjalainen, J, Laibson, D, Lichtenstein, P, Liewald, D C, Magnusson, P K, Martin, N G, McGue, M, McMahon, G, Pedersen, N L, Pinker, S, Porteous, D J, Posthuma, D, Rivadeneira, F, Smith, B H, Starr, J M, Tiemeier, H, Timpson, N J, Trzaskowski, M, Uitterlinden, A G, Verhulst, F C, Ward, M E, Wright, M J, Davey Smith, G, Deary, I J, Johannesson, M, Plomin, R, Visscher, P M, Benjamin, D J, Cesarini, D & Koellinger, P D 2014, ' Common genetic variants associated with cognitive performance identified using the proxy-phenotype method. ', Proceedings of the National Academy of Sciences of the United States of America, vol. 111, no. 38, pp. 13790-13794 . https://doi.org/10.1073/pnas.1404623111 Proceedings of the National Academy of Sciences of the United States of America, 111(38), 13790-13794. National Acad Sciences Proceedings of the National Academy of Sciences of the United States of America, 111(38), 13790-13794. NATL ACAD SCIENCES Proceedings of the National Academy of Sciences of the U.S.A., 111(38), 13790-13794. National Academy of Sciences |
| ISSN: | 0027-8424 0022-3034 0956-7976 1359-4184 0197-4580 1061-4036 1040-7308 0002-9297 0036-8075 0001-8244 0160-2896 0028-0836 2158-3188 1367-4803 1932-6203 |
| DOI: | 10.1073/pnas.1404623111 |
| Popis: | We identify common genetic variants associated with cognitive performance using a two-stage approach, which we call the proxyphenotype method. First, we conduct a genome-wide association study of educational attainment in a large sample (n = 106,736), which produces a set of 69 education-associated SNPs. Second, using independent samples (n = 24,189), we measure the association of these education-associated SNPs with cognitive performance. Three SNPs (rs1487441, rs7923609, and rs2721173) are significantly associated with cognitive performance after correction for multiple hypothesis testing. In an independent sample of older Americans (n = 8,652), we also show that a polygenic score derived from the education-associated SNPs is associated with memory and absence of dementia. Convergent evidence from a set of bioinformatics analyses implicates four specific genes (KNCMA1, NRXN1, POU2F3, and SCRT). All of these genes are associated with a particular neurotransmitter pathway involved in synaptic plasticity, the main cellular mechanism for learning and memory. Refereed/Peer-reviewed |
| Databáze: | OpenAIRE |
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