Local administration of curcumin-loaded nanoparticles effectively inhibits inflammation and bone resorption associated with experimental periodontal disease

Autor: Antonio Claudio Tedesco, Fernanda Regina Godoy Rocha, Dayane de Almeida Brandão, Laura M. G. Zambrano, Carlos Rossa Junior, Fernando Lucas Primo, Raquel P. Marsiglio, Morgana Rodrigues Guimarães-Stabili, Ieda B. Longo
Přispěvatelé: Universidade Estadual Paulista (Unesp), Universidade de São Paulo (USP)
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Scientific Reports
Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
ISSN: 2045-2322
DOI: 10.1038/s41598-018-24866-2
Popis: Made available in DSpace on 2018-12-11T17:19:45Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-12-01 There is evidence indicating that curcumin has multiple biological activities, including anti-inflammatory properties. In vitro and in vivo studies demonstrate that curcumin may attenuate inflammation and the connective tissue destruction associated with periodontal disease. Most of these studies use systemic administration, and considering the site-specific nature of periodontal disease and also the poor pharmacodynamic properties of curcumin, we conducted this proof of principle study to assess the biological effect of the local administration of curcumin in a nanoparticle vehicle on experimental periodontal disease. We used 16 rats divided into two groups of 8 animals according to the induction of experimental periodontal disease by bilateral injections of LPS or of the vehicle control directly into the gingival tissues 3×/week for 4 weeks. The same volume of curcumin-loaded nanoparticles or of nanoparticle vehicle was injected into the same sites 2×/week. μCT analysis showed that local administration of curcumin resulted in a complete inhibition of inflammatory bone resorption and in a significant decrease of both osteoclast counts and of the inflammatory infiltrate; as well as a marked attenuation of p38 MAPK and NF-kB activation. We conclude that local administration of curcumin-loaded nanoparticles effectively inhibited inflammation and bone resorption associated with experimental periodontal disease. Department of Diagnosis and Surgery School of Dentistry at Araraquara-Univ Estadual Paulista (UNESP) Faculty of Pharmaceutical Sciences of Araraquara Department of Bioprocess and Biotechnology Sao Paulo State University (UNESP) Department of Chemistry Center of Nanotechnology and Tissue Engineering Photobiology and Photomedicine Research Group Faculty of Philosophy Sciences and Letters of Ribeirao Preto University of Sao Paulo Department of Diagnosis and Surgery School of Dentistry at Araraquara-Univ Estadual Paulista (UNESP) Faculty of Pharmaceutical Sciences of Araraquara Department of Bioprocess and Biotechnology Sao Paulo State University (UNESP)
Databáze: OpenAIRE
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