Xanthohumol for Human Malignancies: Chemistry, Pharmacokinetics and Molecular Targets
| Autor: | Sarah Jamieson, Hiroaki Taniguchi, Vancha Harish, Devesh Tewari, Anupam Bishayee, Effi Haque, Magdalena Śmiech |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Humulus lupulus L Humulus lupulus molecular targets QH301-705.5 proliferation Flavonoid Review Pharmacology Catalysis Inorganic Chemistry chemistry.chemical_compound Pharmacokinetics prevention Neoplasms medicine Animals Humans cancer Physical and Theoretical Chemistry Biology (General) Humulus Molecular Biology QD1-999 Spectroscopy chemistry.chemical_classification Flavonoids Propiophenones therapy Cancer prevention biology Chemistry Organic Chemistry apoptosis Cancer food and beverages General Medicine Antimicrobial medicine.disease biology.organism_classification Antineoplastic Agents Phytogenic xanthohumol Computer Science Applications Xanthohumol Molecular targets Female |
| Zdroj: | International Journal of Molecular Sciences, Vol 22, Iss 4478, p 4478 (2021) International Journal of Molecular Sciences |
| ISSN: | 1661-6596 1422-0067 |
| Popis: | Xanthohumol (XH) is an important prenylated flavonoid that is found within the inflorescence of Humulus lupulus L. (Hop plant). XH is an important ingredient in beer and is considered a significant bioactive agent due to its diverse medicinal applications, which include anti-inflammatory, antimicrobial, antioxidant, immunomodulatory, antiviral, antifungal, antigenotoxic, antiangiogenic, and antimalarial effects as well as strong anticancer activity towards various types of cancer cells. XH acts as a wide ranging chemopreventive and anticancer agent, and its isomer, 8-prenylnaringenin, is a phytoestrogen with strong estrogenic activity. The present review focuses on the bioactivity of XH on various types of cancers and its pharmacokinetics. In this paper, we first highlight, in brief, the history and use of hops and then the chemistry and structure–activity relationship of XH. Lastly, we focus on its prominent effects and mechanisms of action on various cancers and its possible use in cancer prevention and treatment. Considering the limited number of available reviews on this subject, our goal is to provide a complete and detailed understanding of the anticancer effects of XH against different cancers. |
| Databáze: | OpenAIRE |
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