Levodropropizine reduces capsaicin- and substance P-induced plasma extravasation in the rat trachea
| Autor: | Pierangelo Geppetti, Jay A. Nadel, Luisa Daffonchio, Olivier Huber, Claude Bertrand, Claudio Omini, Isao Yamawaki |
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| Rok vydání: | 1993 |
| Předmět: |
Agonist
medicine.medical_specialty medicine.drug_class Urinary Bladder Substance P Blood Pressure In Vitro Techniques Capillary Permeability chemistry.chemical_compound Heart Rate Internal medicine Peripheral Nervous System medicine Animals Platelet Activating Factor Levodropropizine Evans Blue Pharmacology Platelet-activating factor Dose-Response Relationship Drug business.industry Extravasation Rats Inbred F344 Rats Trachea Antitussive Agents Endocrinology chemistry Mechanism of action Capsaicin Propylene Glycols medicine.symptom business medicine.drug Extravasation of Diagnostic and Therapeutic Materials Muscle Contraction |
| Zdroj: | European journal of pharmacology. 243(1) |
| ISSN: | 0014-2999 |
| Popis: | We investigated the effect of the non-opioid, peripherally acting antitussive agent levodropropizine to reduce neurogenic plasma extravasation in the rat trachea. Levodropropizine (10, 50 and 200 mg/kg) reduced in a dose-dependent manner the extravasation of Evans blue dye evoked by capsaicin. Levodropropizine inhibited also substance P-evoked extravasation, whereas it did not affect the extravasation evoked by platelet activating factor. Levodropropizine (10 and 100 microM) did not affect the contraction produced by [Sar9,Met(O2)11]substance P, a selective agonist for tachykinin NK1 receptors, in the rat urinary bladder in vitro. These data indicate that levodropropizine inhibits capsaicin-induced plasma extravasation: (a) acting at a postjunctional level; (b) exhibiting neuropeptide selectivity and; (c) via a mechanism independent of tachykinin NK1 receptor blockade. Irrespective of the mechanism, this novel antiinflammatory action of levodropropizine underlines its potential role in inflammatory airway diseases such as bronchial asthma. |
| Databáze: | OpenAIRE |
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