Vascular endothelial growth factor augments the healing of demineralized bone matrix grafts
| Autor: | M. Bendeus, El-Mofty Sherif, Ricky W. K. Wong, A. Bakr M. Rabie, Gamal M. Basma, Bassem Emad |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
medicine.medical_specialty
biology business.industry Demineralized bone matrix VEGF receptors Vascular Endothelial Growth Factor dBm General Medicine Grafting Surgery Allogeneic graft Vascular endothelial growth factor Demineralized Bone Matrix chemistry.chemical_compound Bone induction chemistry Clinical investigation medicine biology.protein Bone formation business |
| Zdroj: | International Journal of Surgery. (3):160-166 |
| ISSN: | 1743-9191 |
| DOI: | 10.1016/j.ijsu.2006.04.005 |
| Popis: | AimTo produce a totally allogeneic graft material that would eliminate the need for harvesting the autogenous bone from patients.Materials and methodsThirty-six (10×5mm) defects were created in the parietal bones of 18 rabbits. Two experimental groups of 12 defects each were grafted with DBMIM alone and VEGF+DBMIM, respectively. The remaining 12 defects were left empty as controls, and sacrificed on days 14, 30 and 60. Two rabbits, with four defects, of each group were sacrificed on day 14, 30 and 60 post grafting. The defects were retrieved for histological evaluation and quantitative analysis.ResultsNo bone formed across the defect in the controls. The difference in the amount of new bone formation between experimental groups was significant especially 30 and 60days post grafting (p |
| Databáze: | OpenAIRE |
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