Reduction in Serum Levels of Adhesion Molecules, Interleukin-6 and C-reactive Protein Following Short-term Low-dose Atorvastatin Treatment in Patients with Non-familial Hypercholesterolemia
| Autor: | Hapizah Md Nawawi, B. A K Khalid, N.S. Osman, Khalid Yusoff |
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| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_specialty Statin Endothelium medicine.drug_class Endocrinology Diabetes and Metabolism Atorvastatin Hypercholesterolemia Clinical Biochemistry Vascular Cell Adhesion Molecule-1 Familial hypercholesterolemia Biochemistry Drug Administration Schedule Endothelial activation Endocrinology Double-Blind Method Internal medicine medicine Humans Pyrroles Endothelial dysfunction Dose-Response Relationship Drug medicine.diagnostic_test Interleukin-6 business.industry Cell adhesion molecule Biochemistry (medical) General Medicine Middle Aged Intercellular Adhesion Molecule-1 medicine.disease Lipids C-Reactive Protein medicine.anatomical_structure Heptanoic Acids Multivariate Analysis Female Hydroxymethylglutaryl-CoA Reductase Inhibitors E-Selectin business Lipid profile medicine.drug |
| Zdroj: | Hormone and Metabolic Research. 35:479-485 |
| ISSN: | 1439-4286 0018-5043 |
| DOI: | 10.1055/s-2003-41805 |
| Popis: | Hypercholesterolemia causes endothelial dysfunction, an early feature of atherosclerosis, leading to increased production of adhesion molecules and cytokines. The aim of this study was to investigate the effects of three months of treatment with low dose atorvastatin on serum levels of adhesion molecules, interleukin-6 (IL-6) and highly sensitive C-reactive protein (hs-CRP) in patients with non-familial hypercholesterolemia. Fifty-five patients with non-familial hypercholesterolemia were randomized to treatment with atorvastatin 10 mg/day or placebo for 3 months. Soluble intercellular adhesion molecules-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), E-selectin, IL-6 and hs-CRP levels were measured to assess the inflammatory activity of the endothelium. There was a significant reduction in ICAM-1 at 2 weeks (p |
| Databáze: | OpenAIRE |
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