Over-activation of primate subgenual cingulate cortex enhances the cardiovascular, behavioral and neural responses to threat
| Autor: | Hannah F. Clarke, Laith Alexander, Angela C. Roberts, Stephen J. Sawiak, Lauren McIver, Philip L.R. Gaskin, Tim D. Fryer, Christian M Wood, Young T. Hong |
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| Přispěvatelé: | Wood, Christian M. [0000-0003-1267-5032], Gaskin, Philip L. R. [0000-0002-8499-6233], Roberts, Angela C. [0000-0003-2873-157X], Apollo - University of Cambridge Repository, Wood, Christian M [0000-0003-1267-5032], Gaskin, Philip LR [0000-0002-8499-6233], Roberts, Angela C [0000-0003-2873-157X] |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cingulate cortex Male Hydrocortisone Science General Physics and Astronomy Amygdala Gyrus Cinguli General Biochemistry Genetics and Molecular Biology 59 Arousal Cardiovascular Physiological Phenomena 03 medical and health sciences 0302 clinical medicine Heart Rate Positron Emission Tomography Computed Tomography medicine Animals 631/378/1457/1945 Autonomic Pathways Vagal tone 631/378/1457/1601 lcsh:Science Anterior cingulate cortex 631/378/1689/1414 631/378/1689/1831 64 Multidisciplinary 631/378/1689/1300 Behavior Animal business.industry article Callithrix General Chemistry Fear Dorsolateral prefrontal cortex 030104 developmental biology medicine.anatomical_structure 59/78 Antidepressant Female lcsh:Q business Neuroscience 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020) |
| DOI: | 10.17863/cam.59058 |
| Popis: | Stress-related disorders such as depression and anxiety are characterized by enhanced negative emotion and physiological dysfunction. Whilst elevated activity within area 25 of the subgenual anterior cingulate cortex (sgACC/25) has been implicated in these illnesses, it is unknown whether this over-activity is causal. By combining targeted intracerebral microinfusions with cardiovascular and behavioral monitoring in marmosets, we show that over-activation of sgACC/25 reduces vagal tone and heart rate variability, alters cortisol dynamics during stress and heightens reactivity to proximal and distal threat. 18F-FDG PET imaging shows these changes are accompanied by altered activity within a network of brain regions including the amygdala, hypothalamus and dorsolateral prefrontal cortex. Ketamine, shown to have rapid antidepressant effects, fails to reverse elevated arousal to distal threat contrary to the beneficial effects we have previously demonstrated on over-activation induced reward blunting, illustrating the symptom-specificity of its actions. |
| Databáze: | OpenAIRE |
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