Characteristics and risk factors for SARS-CoV-2 in children tested in the early phase of the pandemic: a cross-sectional study, Italy, 23 February to 24 May 2020
| Autor: | Francesca Saretta, Marco Binotti, Idanna Sforzi, Egidio Barbi, Chiara Pilotto, Antonio Gatto, Valentina Moressa, Fabio Cardinale, Enrico Valletta, Alessia Testa, Benedetta Armocida, Marzia Lazzerini, Silvia Fasoli, Stefano Martelossi, Antonella Di Stefano, Federico Marchetti, Margherita Mauro, Ilaria Mariani, Paola Pascolo, Davide Silvagni, Mariasole Conte, Roberta Parrino, Giovanna Villa, Sandra Trapani, Francesca Vaienti, Annamaria Magista, Giuseppina Perricone, Ilaria Liguoro, Elisabetta Miorin, Enrico Felici, Jessica Tibaldi, Paola Berlese, Sara Lega, Gian Luca Trobia, Azzurra Orlandi, Claudia Gioè, Luca Bertacca, Roberto Dall'Amico, Riccardo Lubrano, Danica Dragovic, Antonio Chiaretti, Paolo Biban |
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| Přispěvatelé: | Lazzerini, Marzia, Sforzi, Idanna, Trapani, Sandra, Biban, Paolo, Silvagni, Davide, Villa, Giovanna, Tibaldi, Jessica, Bertacca, Luca, Felici, Enrico, Perricone, Giuseppina, Parrino, Roberta, Gioè, Claudia, Lega, Sara, Conte, Mariasole, Marchetti, Federico, Magista, Annamaria, Berlese, Paola, Martelossi, Stefano, Vaienti, Francesca, Valletta, Enrico, Mauro, Margherita, Dall'Amico, Roberto, Fasoli, Silvia, Gatto, Antonio, Chiaretti, Antonio, Dragovic, Danica, Pascolo, Paola, Pilotto, Chiara, Liguoro, Ilaria, Miorin, Elisabetta, Saretta, Francesca, Trobia, Gian Luca, Di Stefano, Antonella, Orlandi, Azzurra, Cardinale, Fabio, Lubrano, Riccardo, Testa, Alessia, Binotti, Marco, Moressa, Valentina, Barbi, Egidio, Armocida, Benedetta, Mariani, Ilaria |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Epidemiology Cross-sectional study children COVID-19 Italy risk factors Anosmia Disease 03 medical and health sciences 0302 clinical medicine COVID-19 Testing Child Child Preschool Cross-Sectional Studies Female Humans Infant Infant Newborn Risk Factors Pandemics 030225 pediatrics Virology Intensive care Internal medicine medicine 030212 general & internal medicine Preschool Cross-Sectional Studie business.industry Risk Factor Research Public Health Environmental and Occupational Health Odds ratio Ageusia Newborn Confidence interval Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA medicine.symptom business Human |
| Zdroj: | Eurosurveillance |
| Popis: | Background Very few studies describe factors associated with COVID-19 diagnosis in children. Aim We here describe characteristics and risk factors for COVID-19 diagnosis in children tested in 20 paediatric centres across Italy. Methods We included cases aged 0–18 years tested between 23 February and 24 May 2020. Our primary analysis focused on children tested because of symptoms/signs suggestive of COVID-19. Results Among 2,494 children tested, 2,148 (86.1%) had symptoms suggestive of COVID-19. Clinical presentation of confirmed COVID-19 cases included besides fever (82.4%) and respiratory signs or symptoms (60.4%) also gastrointestinal (18.2%), neurological (18.9%), cutaneous (3.8%) and other unspecific influenza-like presentations (17.8%). In multivariate analysis, factors significantly associated with SARS-CoV-2 positivity were: exposure history (adjusted odds ratio (AOR): 39.83; 95% confidence interval (CI): 17.52–90.55; p Conclusion Recommendations for SARS-CoV-2 testing in children should consider the evidence of broader clinical features. Exposure history, fever and anosmia/ageusia are strong risk factors in children for positive SARS-CoV-2 testing, while other symptoms did not help discriminate positive from negative individuals. This study confirms that COVID-19 was a mild disease in the general paediatric population in Italy. Further studies are needed to understand risk, clinical spectrum and outcomes of COVID-19 in children with pre-existing conditions. |
| Databáze: | OpenAIRE |
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