Anti-oxidative function of follicular fluid HDL and outcomes of modified natural cycle-IVF

Autor: I. Homminga, Ruxandra A. Nagy, Uwe J. F. Tietge, Annemieke Hoek, Daniela Andrei, Henk Groen, Josephine L. C. Anderson, Aafke P.A. van Montfoort, Rima H. Mistry
Přispěvatelé: Reproductive Origins of Adult Health and Disease (ROAHD), Value, Affordability and Sustainability (VALUE), Lifestyle Medicine (LM), Center for Liver, Digestive and Metabolic Diseases (CLDM), Obstetrie & Gynaecologie, MUMC+: VMK IVF Lab (9), RS: GROW - R4 - Reproductive and Perinatal Medicine
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
Apolipoprotein E
Apolipoprotein B
DYSLIPIDEMIA
lcsh:Medicine
Antioxidants
chemistry.chemical_compound
0302 clinical medicine
High-density lipoprotein
MARKERS
Pregnancy
Medicine
lcsh:Science
METABOLIC SYNDROME
Multidisciplinary
biology
PLASMA
WOMEN
ELEVATED OXIDATIVE STRESS
Female
lipids (amino acids
peptides
and proteins)
Lipoproteins
HDL
Embryo quality
Endocrine reproductive disorders
Adult
Embryonic Development
Fertilization in Vitro
Predictive markers
Article
PARAMETERS
INFERTILITY
Andrology
03 medical and health sciences
Humans
Sperm Injections
Intracytoplasmic
Cholesterol
business.industry
lcsh:R
ENDOMETRIOSIS
Paraoxonase
nutritional and metabolic diseases
Odds ratio
Embryo
Mammalian
Follicular fluid
Follicular Fluid
030104 developmental biology
chemistry
Oocytes
biology.protein
lcsh:Q
business
HIGH-DENSITY-LIPOPROTEIN
030217 neurology & neurosurgery
Zdroj: Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports
Scientific Reports, 9(1):12817. Nature Publishing Group
Scientific Reports, 9:12817, 1-9. Nature Publishing Group
ISSN: 2045-2322
Popis: High density lipoproteins (HDL) are the main cholesterol carriers in follicular fluid (FF), the natural environment of oocyte development. Additionally, HDL have critical biological functions such as anti-oxidative capacity, which have not been studied in reproduction. Therefore, this study aimed to investigate whether the anti-oxidative function of FF-HDL is associated with fertility outcomes. From 253 women undergoing modified natural cycle (MNC)- IVF at a single academic centre FF and plasma were collected (n = 375 cycles). Anti-oxidative function of FF was mainly attributable to HDL (n = 8; 83%). FF-HDL had a higher anti-oxidative function than plasma HDL (n = 19, P
Databáze: OpenAIRE
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