Associations between changes in city and address specific temperature and QT interval--the VA Normative Aging Study
Autor: | David Sparrow, Brent A. Coull, Antonella Zanobetti, Itai Kloog, Amar J. Mehta, Pantel S. Vokonas, Joel Schwartz |
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Jazyk: | angličtina |
Rok vydání: | 2014 |
Předmět: |
Gerontology
Male Atmospheric Science Mitochondrial Diseases Physiology Epidemiology lcsh:Medicine Coronary Artery Disease 010501 environmental sciences 01 natural sciences Vascular Medicine Standard deviation Coronary artery disease Cohort Studies Electrocardiography 0302 clinical medicine Interquartile range Heart Rate Medicine and Health Sciences Medicine Public and Occupational Health 030212 general & internal medicine Longitudinal Studies Prospective cohort study lcsh:Science Aged 80 and over Multidisciplinary medicine.diagnostic_test Temperature Electrophysiology Physiological Parameters Research Design Cardiovascular Diseases Cardiology Environmental Health Geriatric Cardiology Arrhythmia Cohort study Research Article medicine.medical_specialty Clinical Research Design Research and Analysis Methods QT interval Environmental Epidemiology 03 medical and health sciences Meteorology Internal medicine Heart rate Genetics Humans Obesity Cardiovascular Disease Epidemiology 0105 earth and related environmental sciences Nutrition Aged Clinical Genetics Population Biology business.industry Body Weight lcsh:R Biology and Life Sciences Human Genetics medicine.disease Health Care Diabetes Mellitus and Deafness Geriatrics Earth Sciences lcsh:Q business |
Zdroj: | PLoS ONE, Vol 9, Iss 9, p e106258 (2014) PLoS ONE |
ISSN: | 1932-6203 |
Popis: | Background The underlying mechanisms of the association between ambient temperature and cardiovascular morbidity and mortality are not well understood, particularly for daily temperature variability. We evaluated if daily mean temperature and standard deviation of temperature was associated with heart rate-corrected QT interval (QTc) duration, a marker of ventricular repolarization in a prospective cohort of older men. Methods This longitudinal analysis included 487 older men participating in the VA Normative Aging Study with up to three visits between 2000–2008 (n = 743). We analyzed associations between QTc and moving averages (1–7, 14, 21, and 28 days) of the 24-hour mean and standard deviation of temperature as measured from a local weather monitor, and the 24-hour mean temperature estimated from a spatiotemporal prediction model, in time-varying linear mixed-effect regression. Effect modification by season, diabetes, coronary heart disease, obesity, and age was also evaluated. Results Higher mean temperature as measured from the local monitor, and estimated from the prediction model, was associated with longer QTc at moving averages of 21 and 28 days. Increased 24-hr standard deviation of temperature was associated with longer QTc at moving averages from 4 and up to 28 days; a 1.9°C interquartile range increase in 4-day moving average standard deviation of temperature was associated with a 2.8 msec (95%CI: 0.4, 5.2) longer QTc. Associations between 24-hr standard deviation of temperature and QTc were stronger in colder months, and in participants with diabetes and coronary heart disease. Conclusion/Significance In this sample of older men, elevated mean temperature was associated with longer QTc, and increased variability of temperature was associated with longer QTc, particularly during colder months and among individuals with diabetes and coronary heart disease. These findings may offer insight of an important underlying mechanism of temperature-related cardiovascular morbidity and mortality in an older population. |
Databáze: | OpenAIRE |
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