Associations between changes in city and address specific temperature and QT interval--the VA Normative Aging Study

Autor: David Sparrow, Brent A. Coull, Antonella Zanobetti, Itai Kloog, Amar J. Mehta, Pantel S. Vokonas, Joel Schwartz
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Gerontology
Male
Atmospheric Science
Mitochondrial Diseases
Physiology
Epidemiology
lcsh:Medicine
Coronary Artery Disease
010501 environmental sciences
01 natural sciences
Vascular Medicine
Standard deviation
Coronary artery disease
Cohort Studies
Electrocardiography
0302 clinical medicine
Interquartile range
Heart Rate
Medicine and Health Sciences
Medicine
Public and Occupational Health
030212 general & internal medicine
Longitudinal Studies
Prospective cohort study
lcsh:Science
Aged
80 and over
Multidisciplinary
medicine.diagnostic_test
Temperature
Electrophysiology
Physiological Parameters
Research Design
Cardiovascular Diseases
Cardiology
Environmental Health
Geriatric Cardiology
Arrhythmia
Cohort study
Research Article
medicine.medical_specialty
Clinical Research Design
Research and Analysis Methods
QT interval
Environmental Epidemiology
03 medical and health sciences
Meteorology
Internal medicine
Heart rate
Genetics
Humans
Obesity
Cardiovascular Disease Epidemiology
0105 earth and related environmental sciences
Nutrition
Aged
Clinical Genetics
Population Biology
business.industry
Body Weight
lcsh:R
Biology and Life Sciences
Human Genetics
medicine.disease
Health Care
Diabetes Mellitus and Deafness
Geriatrics
Earth Sciences
lcsh:Q
business
Zdroj: PLoS ONE, Vol 9, Iss 9, p e106258 (2014)
PLoS ONE
ISSN: 1932-6203
Popis: Background The underlying mechanisms of the association between ambient temperature and cardiovascular morbidity and mortality are not well understood, particularly for daily temperature variability. We evaluated if daily mean temperature and standard deviation of temperature was associated with heart rate-corrected QT interval (QTc) duration, a marker of ventricular repolarization in a prospective cohort of older men. Methods This longitudinal analysis included 487 older men participating in the VA Normative Aging Study with up to three visits between 2000–2008 (n = 743). We analyzed associations between QTc and moving averages (1–7, 14, 21, and 28 days) of the 24-hour mean and standard deviation of temperature as measured from a local weather monitor, and the 24-hour mean temperature estimated from a spatiotemporal prediction model, in time-varying linear mixed-effect regression. Effect modification by season, diabetes, coronary heart disease, obesity, and age was also evaluated. Results Higher mean temperature as measured from the local monitor, and estimated from the prediction model, was associated with longer QTc at moving averages of 21 and 28 days. Increased 24-hr standard deviation of temperature was associated with longer QTc at moving averages from 4 and up to 28 days; a 1.9°C interquartile range increase in 4-day moving average standard deviation of temperature was associated with a 2.8 msec (95%CI: 0.4, 5.2) longer QTc. Associations between 24-hr standard deviation of temperature and QTc were stronger in colder months, and in participants with diabetes and coronary heart disease. Conclusion/Significance In this sample of older men, elevated mean temperature was associated with longer QTc, and increased variability of temperature was associated with longer QTc, particularly during colder months and among individuals with diabetes and coronary heart disease. These findings may offer insight of an important underlying mechanism of temperature-related cardiovascular morbidity and mortality in an older population.
Databáze: OpenAIRE
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