Can in vitro maturation overcome cycles with repeated oocyte maturation arrest? A classification system for maturation arrest and a cohort study
| Autor: | Kadir Bakay, Kaan Hatirnaz, Safak Hatirnaz, Michael H. Dahan, Samer Tannus, Ebru Hatirnaz, Alper Başbuğ |
|---|---|
| Přispěvatelé: | [Belirlenecek] |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Meiotic Arrest medicine.medical_treatment Fertilization in Vitro Chorionic Gonadotropin Human chorionic gonadotropin Andrology Cohort Studies 03 medical and health sciences 0302 clinical medicine Medicine Humans 030212 general & internal medicine Retrospective Studies Pregnancy 030219 obstetrics & reproductive medicine In vitro fertilisation urogenital system business.industry Embryogenesis Obstetrics and Gynecology Embryo General Medicine in vitro maturation medicine.disease Oocyte Embryo transfer In vitro maturation In Vitro Oocyte Maturation Techniques medicine.anatomical_structure embryonic development embryonic structures Female pregnancy Follicle Stimulating Hormone business oocyte maturation arrest in vitro fertilization |
| Popis: | Objective To investigate the role of gonadotropin-stimulated and human chorionic gonadotropin (hCG) -primed in vitro oocyte maturation (IVM) in cases of repeated in vitro fertilization (IVF) failure due to various forms of oocyte maturation arrest (OMA). Methods Retrospective cohort study. Results In all, 63 women with IVF failure due to OMA were evaluated in this study. According to the Hatirnaz & Dahan classification, 11 (17.5%) women were OMA type 1, 22 (34.9%) were OMA type 2, 0 were OMA type 3, 11 (17.5%) were OMA type 4, and 19 women were OMA type 5 (30.1%). Fewer oocytes were retrieved in the IVM than in the IVF cycles. No embryos were produced from oocytes collected in the IVM cycles of women with OMA types 1, 2, and 4. In the OMA type 5 group, 9 (47.4%) day 2 embryos and 6 (31.6%) day 3 embryos were obtained. The difference between the groups was statistically significant (P = 0.001, P = 0.002, respectively). Single day 3 embryo transfer was performed for the six patients with OMA type 5 but no clinical pregnancies occurred. Conclusions Follicle-stimulating hormone-stimulated and hCG-primed IVM does not improve oocyte maturation, developmental potential, or pregnancy rates of women with OMA. Future studies directed to re-establishing normal cytoskeletal architecture and machinery, and resumption of meiosis may be beneficial for obtaining mature oocytes. WOS:000600569100001 2-s2.0-85097807863 PubMed: 33216990 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|