Prevalence of RET/PTC Rearrangements in Hashimoto's Thyroiditis and Papillary Thyroid Carcinomas
| Autor: | Paul W. Biddinger, Christy M. Caudill, Yuri E. Nikiforov, Marina N. Nikiforova |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
0301 basic medicine
endocrine system Pathology medicine.medical_specialty Ret gene Oncogene Proteins Fusion endocrine system diseases Carcinoma Papillary Follicular Thyroiditis Pathology and Forensic Medicine Thyroid carcinoma 03 medical and health sciences 0302 clinical medicine Proto-Oncogene Proteins medicine Frozen Sections Humans RNA Messenger Thyroid Neoplasms Thyroid cancer Gene Rearrangement RET/PTC Rearrangement Paraffin Embedding Reverse Transcriptase Polymerase Chain Reaction business.industry Proto-Oncogene Proteins c-ret Thyroid Thyroiditis Autoimmune Receptor Protein-Tyrosine Kinases Cancer medicine.disease 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Surgery Papillary carcinoma Anatomy business |
| Zdroj: | International Journal of Surgical Pathology. 10:15-22 |
| ISSN: | 1940-2465 1066-8969 |
| DOI: | 10.1177/106689690201000104 |
| Popis: | The relationship between Hashimoto's thyroiditis (HT) and follicular cell-derived thy roid cancer remains unclear. Recently, 2 studies reported a 95% prevalence of RET/PTC rearrangements in histologically benign tissue affected by HT, suggesting that multiple occult tumors exist in HT patients with high frequency. We tested the prevalence of RET/PTC rearrangements in 26 HT, in 6 papillary carcinomas arising in the background of HT, and in 27 papillary carcinomas not associated with HT. We detected no RET/PTC rearrangements in HT or papillary carcinomas arising in the background of HT, in contrast to a 33% prevalence among papillary carcinomas not associated with HT. However, the expression of wild-type RET was found in more than half of papillary carcinomas. These results suggest that, if the association be tween HT and thyroid cancer exists, its molecular basis is different from RETIPTC rearrangement. Int J Surg Pathol 10(1):15-22, 2002 |
| Databáze: | OpenAIRE |
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