The porcine TBC1D1 gene: mapping, SNP identification, and association study with meat, carcass and production traits in Italian heavy pigs
| Autor: | Stefania Dall'Olio, Roberta Davoli, Emilio Scotti, Lucia Tognazzi, Luca Buttazzoni, Michela Colombo, Vincenzo Russo, Luca Fontanesi |
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| Přispěvatelé: | Fontanesi L., Colombo M., Tognazzi L., Scotti E., Buttazzoni L., Dall’Olio S., Davoli R., Russo V. |
| Rok vydání: | 2010 |
| Předmět: |
Male
Candidate gene Genotype Swine SNP Single-nucleotide polymorphism Biology Models Biological Polymorphism Single Nucleotide PRODUCTION TRAITS FATNESS Gene mapping Gene Frequency Genetics Animals ITALIAN HEAVY PIGS Allele TBC1D1 Molecular Biology Allele frequency Alleles GTPase-Activating Proteins General Medicine Italy Mutation Female |
| Zdroj: | Molecular biology reports. 38(2) |
| ISSN: | 1573-4978 |
| Popis: | TBC1D1 [TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1] is a Rab-GTPase-activating related protein implicated in regulating the trafficking of glucose transporter 4 (GLUT4 or SLC2A4) storage vesicles to the cell surface in response to insulin and AMPK-activating stimuli in skeletal muscle. Mutations in the human and mouse TBC1D1 genes confer risk of obesity or leanness. We identified five single nucleotide polymorphisms (SNPs) in the porcine TBC1D1 gene. One of them (FN677935:g.219G>A) was genotyped either by high resolution melting and PCR-RFLP analyses to study allele frequencies in a few pig breeds and evaluate association with meat production and carcass traits in five groups of sib-tested pigs of Italian Large White and Italian Duroc breeds. The g.219G>A SNP was associated (P < 0.05) with ham weight, back fat thickness and lean cuts content in Italian Large White and with visible intermuscular fat in Italian Duroc pigs. |
| Databáze: | OpenAIRE |
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