Hemoglobin mass and intravascular volume kinetics during and after exposure to 3,454-m altitude
| Autor: | Jens P. Goetze, Carsten Lundby, Stefanie Keiser, Anne-Kristine Meinild Lundby, Matthias P. Hilty, Mike Hug, Peter Vestergaard Rasmussen, Christoph Siebenmann, Adrian Cathomen |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Erythrocyte Indices Male Physiology Kinetics Mineralogy chemistry.chemical_element Motor Activity 030204 cardiovascular system & hematology Plasma volume Oxygen Hemoglobins Young Adult 03 medical and health sciences 0302 clinical medicine Altitude Physiology (medical) Intravascular volume status medicine Humans Blood Volume Chromatography Chemistry 030229 sport sciences Hypoxia (medical) Effects of high altitude on humans Adaptation Physiological Female Hemoglobin medicine.symptom |
| Zdroj: | Journal of Applied Physiology. 119:1194-1201 |
| ISSN: | 1522-1601 8750-7587 |
| DOI: | 10.1152/japplphysiol.01121.2014 |
| Popis: | High altitude (HA) exposure facilitates a rapid contraction of plasma volume (PV) and a slower occurring expansion of hemoglobin mass (Hbmass). The kinetics of the Hbmassexpansion has never been examined by multiple repeated measurements, and this was our primary study aim. The second aim was to investigate the mechanisms mediating the PV contraction. Nine healthy, normally trained sea-level (SL) residents (8 males, 1 female) sojourned for 28 days at 3,454 m. Hbmasswas measured and PV was estimated by carbon monoxide rebreathing at SL, on every 4th day at HA, and 1 and 2 wk upon return to SL. Four weeks at HA increased Hbmassby 5.26% (range 2.5-11.1%; P < 0.001). The individual Hbmassincreases commenced with up to 12 days of delay and reached a maximal rate of 4.04 ± 1.02 g/day after 14.9 ± 5.2 days. The probability for Hbmassto plateau increased steeply after 20–24 days. Upon return to SL Hbmassdecayed by −2.46 ± 2.3 g/day, reaching values similar to baseline after 2 wk. PV, aldosterone concentration, and renin activity were reduced at HA ( P < 0.001) while the total circulating protein mass remained unaffected. In summary, the Hbmassresponse to HA exposure followed a sigmoidal pattern with a delayed onset and a plateau after ∼3 wk. The decay rate of Hbmassupon descent to SL did not indicate major changes in the rate of erythrolysis. Moreover, our data support that PV contraction at HA is regulated by the renin-angiotensin-aldosterone axis and not by changes in oncotic pressure. |
| Databáze: | OpenAIRE |
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