Messing with βc: A unique receptor with many goals
| Autor: | Tracy L. Nero, Winnie L. Kan, Angel F. Lopez, Timothy R. Hercus, Karen S. Cheung Tung Shing, Denis Tvorogov, Michael W. Parker |
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| Přispěvatelé: | Kan, Winnie L, Cheung Tung Shing, Karen S, Nero, Tracy L, Hercus, Timothy R, Tvorogov, Denis, Parker, Michael W, Lopez, Angel F |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_treatment
Immunology Inflammation Biology pleiotropy medicine Humans Immunology and Allergy Receptor Leukemia SARS-CoV-2 receptor activation COVID-19 Colony-stimulating factor medicine.disease cytokines Pleiotropy (drugs) Cytokine medicine.anatomical_structure inflammation Bone marrow medicine.symptom Signal transduction signaling Cytokine storm Goals Neuroscience |
| Zdroj: | Seminars in Immunology. 54:101513 |
| ISSN: | 1044-5323 |
| Popis: | Our understanding of the biological role of the βc family of cytokines has evolved enormously since their initial identification as bone marrow colony stimulating factors in the 1960′s. It has become abundantly clear over the intervening decades that this family of cytokines has truly astonishing pleiotropic capacity, capable of regulating not only hematopoiesis but also many other normal and pathological processes such as development, inflammation, allergy and cancer. As noted in the current pandemic, βc cytokines contribute to the cytokine storm seen in acutely ill COVID-19 patients. Ongoing studies to discover how these cytokines activate their receptor are revealing insights into the fundamental mechanisms that give rise to cytokine pleiotropy and are providing tantalizing glimpses of how discrete signaling pathways may be dissected for activation with novel ligands for therapeutic benefit. Refereed/Peer-reviewed |
| Databáze: | OpenAIRE |
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