LBA69 Impact of the COVID-19 pandemic on management of medical cancer treatments and psychological consequence for the patients
| Autor: | G. Binarelli, Florence Joly, J.-M. Grellard, B. Legrand, Fabrice Jardin, Alexandra Leconte, A. Faveyrial, Manfred A. Lange, M. Fernette, J. Lequesne, Bénédicte Clarisse, Olivier Rigal, Laure Tron, D. Richard, L. F. Pépin, Chantal Rieux, R. Travers, A. Morel, E. Bastien, François Gernier |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Chemotherapy medicine.medical_specialty business.industry medicine.medical_treatment Medical record Cancer SARS-CoV-2 and cancer macromolecular substances Disease Hematology medicine.disease Targeted therapy Clinical trial 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Quality of life Oncology 030220 oncology & carcinogenesis Internal medicine medicine Lung cancer business |
| Zdroj: | Annals of Oncology |
| ISSN: | 0923-7534 |
| DOI: | 10.1016/j.annonc.2020.08.2310 |
| Popis: | Background: Treated cancer patients (pts) are at high risk to develop severe COVID-19 evolution and guidelines proposed some preventive medical oncologic treatments (tt) adjustments Pts had to face with this unprecedented situation, as caregivers forced to suddenly adjust their practices We assessed the pandemic-induced therapeutic modifications of pts cancer tt and the psychological impact on pts and caregivers Methods: This prospective French study was initiated among pts with solid/hematologic malignancy receiving a medical tt during the lockdown in outpatient departments of 2 cancer centers Tt modifications were collected from medical records Perceived and post-traumatic stress (PSS, IES-R), sleep (ISI), quality of life QoL (Fact-G) and cognitive complaint (Fact-Cog) were reported at baseline (during the lockdown) and will be collected at 3 and 6 months PSS and professional burnout/self-efficacy (MBI, GSES) were also reported by caregivers Results: Baseline clinical data are available for 621 pts and questionnaires for 575 pts (93%) and 73 caregivers Pts and caregivers median ages were 64 [24-89] and 40 [22-63], 69% and 81% women Caregivers were mainly nurses (48%) and oncologists (30%) 98% of pts had solid tumors, 59% with metastatic disease and 47% de novo treated Main tts included chemotherapy (72%), immunotherapy (31%) and targeted therapy (13%), 37% starting during the lockdown 27% of pts had tt modifications including 30% adapted monitoring (mainly phone-consultation), 15% tt interruptions, 32% postponed tt, 19% administration rhythm modifications, more frequently among lung cancer, tt initiated before lockdown, immunotherapy and targeted therapy Severe perceived stress, post-traumatic stress and insomnia were observed in 6%, 21% and 24% of pts More pts with tt modifications presented severe post-traumatic stress (27% vs 19%, p=0 05) Tt modifications did not impact on QoL/cognition Perceived stress score was higher among caregivers than pts (p=0 035) but 2/3 reported professional accomplishment and self efficacy Conclusions: Lockdown due to COVID-19 induced tt modification in 1/4 of pts with a majored post-traumatic stress Despite a high level of stress, caregivers coped with the situation Clinical trial identification: NCT04366154, registered on 2020, April, 16th Legal entity responsible for the study: Comprehensive Cancer Centre Francois Baclesse, Caen France Funding: French Fondation ARC (Cancer Research Association) Disclosure: All authors have declared no conflicts of interest |
| Databáze: | OpenAIRE |
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