Structure–activity relationship of avocadyne
| Autor: | Tariq A Akhtar, Kevin A Rea, George A. O'Doherty, Richard W. Smith, Vitor L S Cunha, Xiaofan Liu, Angelo D'Alessandro, Paul A. Spagnuolo, Nawaz Ahmed, Todd L. Lowary, Mark D. Minden, Jerry Vockley, Matthew Tcheng |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Cell Survival Stereochemistry Mice SCID Health benefits Antiviral Agents Article Mitochondrial fatty acid Mice Structure-Activity Relationship 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine In vivo Cell Line Tumor Animals Humans Structure–activity relationship Beta oxidation Persea Fatty Acids Stereoisomerism General Medicine Lipid Metabolism Triple bond In vitro Mitochondria Leukemia Myeloid Acute 030104 developmental biology chemistry Polyketides 030220 oncology & carcinogenesis Acetogenin Oxidation-Reduction Food Science |
| Zdroj: | Food Funct |
| ISSN: | 2042-650X 2042-6496 |
| DOI: | 10.1039/d1fo00693b |
| Popis: | Avocado consumption is associated with numerous health benefits. Avocadyne is a terminally unsaturated, 17-carbon long acetogenin found almost exclusively within avocados with noted anti-leukemia and anti-viral properties. In this study, specific structural features such as the terminal triple bond, odd number of carbons, and stereochemistry are shown to be critical to its ability to suppress mitochondrial fatty acid oxidation and impart selective activity in vitro and in vivo. Together, this is the first study to conduct a structure-activity analysis on avocadyne and outline the chemical moieties critical to fatty acid oxidation suppression. |
| Databáze: | OpenAIRE |
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