Influence of surface chemistry of mesoporous alumina with wide pore distribution on controlled drug release
| Autor: | Rajesh Hegde, Aninda J. Bhattacharyya, Shobhna Kapoor |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Drug
Surface Properties Stereochemistry Diffusion media_common.quotation_subject Pharmaceutical Science Ibuprofen Dosage form Drug Delivery Systems X-Ray Diffraction Pharmacokinetics Spectroscopy Fourier Transform Infrared Aluminum Oxide medicine media_common Drug Carriers Chemistry Temperature Hydrogen-Ion Concentration Kinetics Models Chemical Pharmaceutical Preparations Chemical engineering Delayed-Action Preparations Thermogravimetry Surface modification Spectrophotometry Ultraviolet Mesoporous material Drug carrier Hydrophobic and Hydrophilic Interactions Porosity medicine.drug |
| Zdroj: | Journal of Controlled Release. 140:34-39 |
| ISSN: | 0168-3659 |
| DOI: | 10.1016/j.jconrel.2009.07.015 |
| Popis: | The crucial role of the drug carrier surface chemical moeities on the uptake and in vitro release of drug is discussed here in a systematic manner. Mesoporous alumina with a wide pore size distribution (2-7 nm) functionalized with various hydrophilic and hydrophobic surface chemical groups was employed as the carrier for delivery of the model drug ibuprofen. Surface functionalization with hydrophobic groups resulted in low degree of drug loading (approximately 20%) and fast rate of release (85% over a period of 5 h) whereas hydrophilic groups resulted in a significantly higher drug payloads (21%-45%) and slower rate of release (12%-40% over a period of 5 h). Depending on the chemical moiety, the diffusion controlled ( proportional, varianttime(-)(0.5)) drug release was additionally observed to be dependent on the mode of arrangement of the functional groups on the alumina surface as well as on the pore characteristics of the matrix. For all mesoporous alumina systems the drug dosages were far lower than the maximum recommended therapeutic dosages (MRTD) for oral delivery. We envisage that the present study would aid in the design of delivery systems capable of sustained release of multiple drugs. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect