CD20 is associated with a small mature plasma cell morphology and t(11;14) in multiple myeloma
Autor: | Hervé Avet-Loiseau, Philippe Moreau, Richard Garand, Danielle Pineau, Régis Bataille, Nelly Robillard, Harousseau Jl, Marie-Josée Rapp |
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Rok vydání: | 2003 |
Předmět: |
Pathology
medicine.medical_specialty Immunology Plasma Cells Statistics as Topic Chromosomal translocation Biology Plasma cell Biochemistry Translocation Genetic Andrology Immunophenotyping Antigen immune system diseases hemic and lymphatic diseases Cytology Immunopathology medicine Humans Prospective Studies Multiple myeloma Cell Size CD20 Chromosomes Human Pair 14 Chromosomes Human Pair 11 Cell Biology Hematology medicine.disease Antigens CD20 medicine.anatomical_structure biology.protein Multiple Myeloma |
Zdroj: | Blood. 102(3) |
ISSN: | 0006-4971 |
Popis: | CD20 has been reinvestigated in 66 patients with multiple myeloma (MM). Twelve of the patients (18%) expressed CD20, including 5 of 50 patients at diagnosis presenting 100% CD20+ cells. Seven (58%) of 12 CD20+ patients with MM had a small mature plasma cell morphology as opposed to 4 (7%) of 54 with CD20- MM (P = .0001). Of note, 10 (83%) of 12 patients with CD20+ MM had t(11;14) as opposed to 5 of 54 (9%) CD20- patients (P < .001). All the patients with 100% CD20+ cells presented with t(11;14) and 4 of 5 with a small mature plasma cell morphology. Thus, 66% of the patients with t(11;14) expressed CD20, whereas only 4% of the 51 patients lacking such translocation expressed CD20 (P < .0001). In conclusion, CD20 expression is associated with small mature plasma cell morphology and with t(11;14) in patients with MM. |
Databáze: | OpenAIRE |
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