Ruthenium-catalyzed synthesis of indole derivatives from N-aryl-2-aminopyridines and alpha-carbonyl sulfoxonium ylides
| Autor: | Guosheng Huang, Haojie Ma, Wa-Fa Tian, Xiao-Qiang Zhou, Xinfeng Cui, Fang-Peng Hu, Zihui Ban, Zhenzhen Zhan |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Indole test
Annulation 010405 organic chemistry Aryl Organic Chemistry chemistry.chemical_element 010402 general chemistry 01 natural sciences Biochemistry Combinatorial chemistry 0104 chemical sciences Ruthenium Catalysis chemistry.chemical_compound chemistry Functional group Physical and Theoretical Chemistry Selectivity Aminopyridines |
| Zdroj: | Organicbiomolecular chemistry. 17(2) |
| ISSN: | 1477-0539 |
| Popis: | Indole is a ubiquitous structural motif with important applications in many areas of chemistry. Given this, a simple and efficient Ru(II)-catalyzed synthesis of indole via intermolecular annulation of N-aryl-2-aminopyridines and sulfoxonium ylides was proposed and accomplished. Excellent selectivity and good functional group tolerance of this transformation were observed. This protocol provides easy access to a wide variety of useful indoles in the presence of a commercially available [Ru(p-cymene)Cl2]2 catalyst. A possible mechanism for the reaction pathway was also proposed. More importantly, this reaction will offer a useful method for the construction of enantioenriched indole frameworks. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|