Antidepressant Agomelatine Attenuates Behavioral Deficits and Concomitant Pathology Observed in Streptozotocin-Induced Model of Alzheimer's Disease in Male Rats
| Autor: | Lidia Kortenska, Kalina Ilieva, Dimitrinka Atanasova, Milena Atanasova, Jana Tchekalarova |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Agonist medicine.medical_specialty Elevated plus maze medicine.drug_class Anxiety Hippocampus Neuroprotection Cell loss Streptozocin Rats Sprague-Dawley Melatonin 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Endocrinology Alzheimer Disease Piriform cortex Internal medicine Acetamides Animals Medicine Agomelatine Maze Learning Inflammation Memory Disorders Behavior Radial arm maze Behavior Animal Endocrine and Autonomic Systems business.industry Beta amyloid Alzheimer's disease Streptozotocin Antidepressive Agents Rats 030227 psychiatry Disease Models Animal Exploratory Behavior business 030217 neurology & neurosurgery medicine.drug |
| Popis: | Experimental findings suggest that the melatonin system has a beneficial role in models of Alzheimer's disease (ADs). The aim of the present study was to explore whether the atypical antidepressant agomelatine (Ago), which is a melatonin MT1 and MT2 agonist and 5-HT2C antagonist, is effective against behavioral, biochemical and histological impairments in streptozotocin (STZ)-induced model of ADs in male rats. Male Sprague Dawley rats were treated intraperitoneally (i.p.) with Ago (40 mg/kg) for 30 days starting three months following the intracerebroventricular (icv) injection of STZ. Chronic Ago treatment reduced anxiety-like behavior of STZ-treated rats in the elevated plus maze, increased the preference to saccharine and corrected the spatial memory impairment in the eight-arm radial arm maze test. This melatonin analogue restored STZ-induced biochemical changes, including an increase of beta amyloid (Aβ) protein, and signal markers of inflammation (TNF-alpha and IL-1 beta). Ago exerted partial neuroprotection, specifically in the temporal CA3b subfield of the dorsal hippocampus and temporal piriform cortex. The ability of Ago to alleviate behavioral symptoms and concomitant neuropathological events observed in a model of sporadic ADs suggests that this melatonin alternative can be considered a promising adjuvant in this disease. |
| Databáze: | OpenAIRE |
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