Rhodium(II)-Catalyzed Inter- and Intramolecular Enantioselective Cyclopropanations with Alkyl-Diazo(triorganylsilyl)acetates
| Autor: | Fabienne Lacrampe, Paul Müller |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
chemistry.chemical_classification
Silylation Cyclopropanation Organic Chemistry Diastereomer Enantioselective synthesis chemistry.chemical_element General Medicine Biochemistry Medicinal chemistry Catalysis Rhodium Inorganic Chemistry chemistry.chemical_compound chemistry Intramolecular force ddc:540 Drug Discovery Organic chemistry Diazo Carboxylate Physical and Theoretical Chemistry Alkyl |
| Zdroj: | Helvetica Chimica Acta, Vol. 87, No 11 (2004) pp. 2848-2859 |
| ISSN: | 1522-2667 0931-7597 0018-019X |
| DOI: | 10.1002/chin.200513040 |
| Popis: | The intermolecular cyclopropanation of styrene with ethyl diazo(triethylsilyl)acetate (1a) proceeds at room temperature in the presence of chiral RhII carboxylate catalysts derived from imide‐protected amino acids and affords mixtures of trans‐ and cis‐cyclopropane derivatives 2a in up to 72% yield but with modest enantioselectivities ( |
| Databáze: | OpenAIRE |
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