Supplementary Figures S1 - S3 from Real-Time Intravital Imaging Establishes Tumor-Associated Macrophages as the Extraskeletal Target of Bisphosphonate Action in Cancer

Autor: Michael J. Rogers, Tri Giang Phan, Katherine Weilbaecher, Alexander Swarbrick, Peter I. Croucher, Charles E. McKenna, Boris Kashemirov, Shuting Sun, Akira Nguyen, Andrew Parker, Nicholas Pocock, Jenny Down, Naveid Ali, Julie Jurczyluk, Gemma Shay, Simon Junankar
Rok vydání: 2023
Popis: Supplementary Figure S1. Fluorescently-labelled bisphosphonate is present in the macrophage-rich region of 4T1 mammary tumours in vivo. Supplementary Figure S2. N-BP colocalises with microcalcifications, detected by calcein labelling in 4T1 mammary tumours. Supplementary Figure S3. TAMs do not take up N-BP as efficiently in the B16.F10 melanoma model compared to the 4T1 mammary tumour model.
Databáze: OpenAIRE