Biological Activity of Naturally Derived Naphthyridines
| Autor: | Ewa Barg, Anna Wójcicka, Gabriela Chabowska |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Aquatic Organisms
Phytochemicals Pharmaceutical Science Organic chemistry biological activity Review alkaloids 01 natural sciences aaptamine Analytical Chemistry QD241-441 heterocyclic compounds Biological property Drug Discovery Canthin-6-one natural compounds Animals Humans Physical and Theoretical Chemistry Infectious diseases treatment naphthyridines 010405 organic chemistry Chemistry pyridoacridines Biological activity Plants Combinatorial chemistry 0104 chemical sciences 010404 medicinal & biomolecular chemistry Nitrogen atom Chemistry (miscellaneous) canthin-6-one Molecular Medicine |
| Zdroj: | Molecules, Vol 26, Iss 4324, p 4324 (2021) Molecules |
| ISSN: | 1420-3049 |
| Popis: | Marine and terrestrial environments are rich sources of various bioactive substances, which have been used by humans since prehistoric times. Nowadays, due to advances in chemical sciences, new substances are still discovered, and their chemical structures and biological properties are constantly explored. Drugs obtained from natural sources are used commonly in medicine, particularly in cancer and infectious diseases treatment. Naphthyridines, isolated mainly from marine organisms and terrestrial plants, represent prominent examples of naturally derived agents. They are a class of heterocyclic compounds containing a fused system of two pyridine rings, possessing six isomers depending on the nitrogen atom’s location. In this review, biological activity of naphthyridines obtained from various natural sources was summarized. According to previous studies, the naphthyridine alkaloids displayed multiple activities, i.a., antiinfectious, anticancer, neurological, psychotropic, affecting cardiovascular system, and immune response. Their wide range of activity makes them a fascinating object of research with prospects for use in therapeutic purposes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|