| Popis: |
The study was set up to investigate the role of Interleukin-31 (IL-31) in atopic dermatitis. IL-31 is a member of the innate immune system, it is preferentially expressed by Th2 cells, and is highly recognized in AD skin lesions. Ninety persons from both genders are included in the study, forty-five of them were patients and the same number were as control. Blood samples were taken from both groups and ELISA ready kit was used to estimate the sera levels of IL-31. The findings of the current study referred that the young adult, and female gender were more affected by Atopic Dermatitis, and the female to male ratio was 1.14: 1. On the other hand, the results indicated there were elevated sera levels of IL-31 in AD patients in contrast to the controls group. Also, IL-31 had a positive correlation with the severity of AD with no significant (r=0.5, P˃0.05). Conclusion: we concluded that the high levels of IL-31in AD and its positive correlation with Atopic dermatitis severity, revealed that IL-31 may have a role in the bad prognosis of AD. |
