Bioactivity Evaluation Of Cudraxanthone I, Neocyclomorusin And (9 Beta H)-3 Beta-Acetoxylanosta-7,24-Diene Isolated From Milicia Excelsa Welw. C. C. Berg (Moraceae)
| Autor: | Merve B. Koc, Feyza Oke-Altuntas, Ibrahim Demirtas, Gilbert D W F Kapche, Judith L. Nantchouang Ouete, Bonaventure T. Ngadjui |
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| Rok vydání: | 2016 |
| Předmět: |
Antioxidant
Traditional medicine biology 010405 organic chemistry Chemistry medicine.medical_treatment Organic Chemistry Milicia excelsa medicine.disease_cause biology.organism_classification Antimicrobial Moraceae 01 natural sciences 0104 chemical sciences HeLa 010404 medicinal & biomolecular chemistry Biochemistry Staphylococcus aureus visual_art medicine visual_art.visual_art_medium Cytotoxic T cell Bark General Pharmacology Toxicology and Pharmaceutics |
| Popis: | This study aimed to investigate the cytotoxic, antioxidant, and antimicrobial activities of three compounds isolated from the methanolic extract of the roots bark of Milicia excelsa (Moraceace) namely cudraxanthone I (1), neocyclomorusin (2) and (9 beta H)-3 beta-acetoxylanosta-7,24-diene (3). The cytotoxic activities of the compounds were determined using the xCELLigence system (Real Time Cell Analyzer). The compounds of cudraxanthone I and neocyclomorusin exhibited the excellent cytotoxic effects on the growth of human cervical epithelioid carcinoma (HeLa) cell lines (IC50 < 10 A mu g/mL). Among the compounds; neocyclomorusin showed the highest radical scavenging activity (IC50 = 0.73 A +/- 0.01 mg/mL). The compounds exhibited low antimicrobial activity against Staphylococcus aureus ATCC 25923. This study supports the documented medicinal effects of the compounds and opens up the possibilities of pharmaceutical applications. |
| Databáze: | OpenAIRE |
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