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— Chronic lymphocytic leukemia (CLL) is considered the most common B-cell leukemia. Its clinical course is highly variable and depends on clinical, biological and genetic features of leukemic B-cells. Expression of ZAP-70, CD38 and mutated p53 was assessed by flow cytometry methods in 175 B-CLL patients and estimated their impact on disease progression rate (DPR) and overall survival (OS). Fifty-one patients (29%) were ZAP-70(+), 81 (46%) were CD38(+), 24 (13.7%) were p53(+). OS was significantly shorter in CD38(+) patients (94.8 vs. 120 months, p |
