The association of fatty acids with prostate cancer risk
| Autor: | Irena B. King, Laura M. Newcomer, Kristine G. Wicklund, Janet L. Stanford |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
Male medicine.medical_specialty Urology Linoleic acid Population Pilot Projects Adenocarcinoma Statistics Nonparametric Interviews as Topic Prostate cancer chemistry.chemical_compound Risk Factors Prostate Fatty Acids Omega-6 Internal medicine Fatty Acids Omega-3 Biomarkers Tumor medicine Humans Risk factor education Aged education.field_of_study business.industry Erythrocyte Membrane Case-control study Prostatic Neoplasms Cancer Middle Aged medicine.disease Dietary Fats Endocrinology medicine.anatomical_structure Oncology chemistry Case-Control Studies Fatty Acids Unsaturated business |
| Zdroj: | The Prostate. 47:262-268 |
| ISSN: | 1097-0045 0270-4137 |
| DOI: | 10.1002/pros.1070 |
| Popis: | BACKGROUND Animal studies indicate that omega-6 fatty acids promote and omega-3 fatty acids inhibit tumor development. This pilot study was designed to evaluate whether these fatty acids are associated with human prostate cancer. METHODS Levels of erythrocyte membrane omega-3 and omega-6 fatty acids were determined for 67 incident prostate cancer cases and 156 population-based controls. RESULTS Prostate cancer risk was increased in the highest compared to the lowest quartile of α-linolenic acid (OR = 2.6, 95% CI = 1.1–5.8, trend P = 0.01). Positive associations were also observed with higher levels of linoleic acid (OR = 2.1, 95% CI = 0.9–4.8) and total omega-6 fatty acids (OR = 2.3, 95% CI = 1.0–5.4). CONCLUSIONS Results are consistent with other studies showing that linoleic and total omega-6 fatty acids increase risk of prostate cancer. Contrary to animal studies, α-linolenic acid was also positively associated with risk. Further research will be required to clarify the role of these fatty acids in human prostate cancer. Prostate 47:262–268, 2001. © 2001 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
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