Spinal Cord Injury: Animal Models, Imaging Tools and the Treatment Strategies
| Autor: | Zuzana Mojzisova, Isabelle Fournier, Filip Humenik, Adriana-Natalia Murgoci, Marcela Maloveska, Veronika Cubinkova, Milan Cizek, Michel Salzet, Dasa Cizkova |
|---|---|
| Přispěvatelé: | Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U 1192 (PRISM), Université de Lille-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Slovak Academy of Sciences (SAS), University of Veterinary Medicine and Pharmacy [Košice, Slovakia], Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), SALZET, Michel |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
[SDV]Life Sciences [q-bio] Neuroimaging Spinal cord injury Bioinformatics Exosomes Biochemistry Umbilical cord Neurosurgical Procedures Imaging Biomaterials 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine medicine Paralysis Stem cells Animals Humans Spinal Cord Injuries business.industry Mesenchymal stem cell General Medicine medicine.disease Spinal cord Magnetic Resonance Imaging Microvesicles 3. Good health Animal models [SDV] Life Sciences [q-bio] Disease Models Animal 030104 developmental biology medicine.anatomical_structure Treatment Outcome Positron-Emission Tomography Bone marrow Stem cell medicine.symptom business Tomography X-Ray Computed 030217 neurology & neurosurgery Stem Cell Transplantation |
| Zdroj: | Neurochemical Research Neurochemical Research, Springer Verlag, 2020, 45 (1), pp.134-143. ⟨10.1007/s11064-019-02800-w⟩ Neurochemical Research, 2020, 45 (1), pp.134-143. ⟨10.1007/s11064-019-02800-w⟩ |
| ISSN: | 0364-3190 1573-6903 |
| DOI: | 10.1007/s11064-019-02800-w⟩ |
| Popis: | International audience; Spinal cord injury (SCI) often leads to irreversible neuro-degenerative changes with life-long consequences. While there is still no effective therapy available, the results of past research have led to improved quality of life for patients suffering from partial or permanent paralysis. In this review we focus on the need, importance and the scientific value of experimental animal models simulating SCI in humans. Furthermore, we highlight modern imaging tools determining the location and extent of spinal cord damage and their contribution to early diagnosis and selection of appropriate treatment. Finally, we focus on available cellular and acellular therapies and novel combinatory approaches with exosomes and active biomaterials. Here we discuss the efficacy and limitations of adult mesenchymal stem cells which can be derived from bone marrow, adipose tissue or umbilical cord blood and its Wharton's jelly. Special attention is paid to stem cell-derived exosomes and smart biomaterials due to their special properties as a delivery system for proteins, bioactive molecules or even genetic material. |
| Databáze: | OpenAIRE |
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