Relationship of the low-density lipoprotein (LDL)/high-density lipoprotein (HDL) index with antioxidant enzymes and with the oxLDL/HDL index
| Autor: | Francisco Mendoza-Carrera, Blanca G. Baez-Duarte, Adriana Nieva-Vazquez, Karla Hilsen García-Aragón, Eduardo Monjaraz-Guzmán, Claudia Valeria Flores-Blanco, Paola Meneses-Zamora, Irma Zamora-Ginez, Karina Luna-De Jesús |
|---|---|
| Rok vydání: | 2023 |
| Předmět: |
Adult
Male medicine.medical_specialty Antioxidant GPX3 medicine.medical_treatment medicine.disease_cause Superoxide dismutase chemistry.chemical_compound Sex Factors High-density lipoprotein Insulin resistance Internal medicine medicine Humans Magnesium Obesity Glutathione Peroxidase biology Superoxide Dismutase Smoking Age Factors General Medicine medicine.disease Lipoproteins LDL Oxidative Stress Cross-Sectional Studies Endocrinology Nails chemistry Low-density lipoprotein biology.protein Female lipids (amino acids peptides and proteins) Insulin Resistance Lipoproteins HDL Oxidative stress Lipoprotein |
| Zdroj: | Gaceta Médica de México. 155 |
| ISSN: | 0016-3813 |
| DOI: | 10.24875/gmm.m20000331 |
| Popis: | Introduction The low-density lipoprotein (LDL)/high-density lipoprotein (HDL) index is a predictive factor for atherosclerosis, which is associated with oxidative modifications. Objective To assess the association of the index with oxidative stress markers. Methods 444 subjects were included and were clinically, anthropometrically and biochemically characterized; superoxide dismutase, glutathione peroxidase 3 (GPx3), magnesium and oxidized LDL (oxLDL) index (oxLDL/HDL) were quantified. Results A decrease of 1.014 units in the LDL/HDL index was associated with a superoxide dismutase increase of 1 unit/mL (p = 0.030), while a decrease of 0.023 units was associated with a GPx3 increase of 1 nmol/min/mL (p < 0.0005). An increase of one unit in the index was associated with an increase of 0.831 in the oxLDL/HDL index (p < 0.05). After controlling for the effect of gender, age, smoking, obesity and insulin resistance, a reduction of 0.001 per index unit was associated with an increase of 1 µg/g of magnesium in the nails (p = 0.020). Conclusions The LDL/HDL index shows an inverse relationship with the antioxidant status and a direct relationship with oxidation status, regardless of other cardiovascular and oxidative stress risk factors. |
| Databáze: | OpenAIRE |
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