The evaluation of HBDH and LDH isoenzymes in cardiac cell necrosis of the rat
| Autor: | J. H. Harleman, R. J. Barrett, E. C. Joseph |
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| Rok vydání: | 1988 |
| Předmět: |
Male
medicine.medical_specialty Necrosis Biology Toxicology Isozyme Cardiac cell chemistry.chemical_compound Hydroxybutyrate Dehydrogenase Isoprenaline Internal medicine Lactate dehydrogenase medicine Animals Humans Tissue Distribution L-Lactate Dehydrogenase Myocardium Isoproterenol Heart Rats Inbred Strains Ldh isoenzymes Coronary heart disease Rats Isoenzymes Endocrinology chemistry Pyrazines Female Myocardial necrosis medicine.symptom medicine.drug |
| Zdroj: | Journal of applied toxicology : JAT. 8(4) |
| ISSN: | 0260-437X |
| Popis: | The total LDH, HBDH and LDH isoenzyme activities were assessed in a number of rat tissues. HBDH did not correlate with LD1 and LD2 isoenzyme activity in tissues with high HBDH activity. HBDH therefore cannot be used as a marker for cardiac necrosis in the rat. In rats treated with isoprenaline and SK&F 94120 at doses producing myocardial necrosis, only the LD1 isoenzymes showed any significant change but only within the first 24 h of treatment. No statistically significant differences were seen in the plasma AST, CK, CK-MB and total LDH activities. |
| Databáze: | OpenAIRE |
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