Autor: |
Joseph C. Devlin, Stanley L. Hazen, Linchen He, Meifan Zhang, Michelle H. Badri, John Alex Chalk, Wei Vivian Li, Mark Brown, Richard Bonneau, Jincheng Wang, Jamie Morton, Thomas Battaglia, Kelly Needles, Kelly V. Ruggles, Jackie Li, Xue-Song Zhang, Maria Gloria Dominguez-Bello, Martin J. Blaser, Christopher M. Strauch, Yue Sandra Yin, Ina Nemet, Fredrik Bäckhed, Zeneng Wang, Kimberly A. Krautkramer, Nicole J. Altomare, Huilin Li, Julia Mount, Abigail J. S. Armstrong, Viviane Liao |
Rok vydání: |
2021 |
Předmět: |
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Zdroj: |
Cell host & microbe, vol 29, iss 8 Cell Host Microbe |
Popis: |
Early-life antibiotic exposure perturbs the intestinal microbiota and accelerates type 1 diabetes (T1D) development in the NOD mouse model. Here, we found that maternal cecal microbiota transfer (CMT) to NOD mice after early-life antibiotic perturbation largely rescued the induced T1D enhancement. Restoration of the intestinal microbiome was significant and persistent, remediating the antibiotic-depleted diversity, relative abundance of particular taxa, and metabolic pathways. CMT also protected against perturbed metabolites and normalized innate and adaptive immune effectors. CMT restored major patterns of ileal microRNA and histone regulation of gene expression. Further experiments suggest a gut-microbiota-regulated T1D protection mechanism centered on Reg3γ, in an innate intestinal immune network involving CD44, TLR2, and Reg3γ. This regulation affects downstream immunological tone, which may lead to protection against tissue-specific T1D injury. |
Databáze: |
OpenAIRE |
Externí odkaz: |
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