Blood metabolic signatures of body mass index: a targeted metabolomics study in the EPIC Cohort
| Autor: | Ruth C. Travis, Raul Zamora-Ros, Julie A. Schmidt, Christina Bamia, Rosario Tumino, Kim Overvad, Magdalena Stepien, José María Huerta, J. Ramón Quirós, Rudolf Kaaks, Ursula Bachlechner, Petra H.M. Peeters, Emilio Sánchez-Cantalejo, Eva Ardanaz, Larraitz Arriola, Claudia Agnoli, Bas Bueno-de-Mesquita, Tilman Kühn, Salvatore Panico, David Achaintre, Marion Carayol, Paolo Vineis, Heiner Boeing, Augustin Scalbert, Antonia Trichopoulou, Antonio Agudo, Pietro Ferrari, Louise Hansen, Sabina Rinaldi, Nicholas J. Wareham, Anne Tjønneland, Kay-Tee Khaw, Domenico Palli, Michael F. Leitzmann, Timothy J. Key, Mazda Jenab, Jan Nilsson, Olle Melander |
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| Přispěvatelé: | Carayol, Marion, Leitzmann, Michael F., Ferrari, Pietro, Zamora ros, Raul, Achaintre, David, Stepien, Magdalena, Schmidt, Julie A., Travis, Ruth C., Overvad, Kim, Tjã¸nneland, Anne, Hansen, Louise, Kaaks, Rudolf, Kã¼hn, Tilman, Boeing, Heiner, Bachlechner, Ursula, Trichopoulou, Antonia, Bamia, Christina, Palli, Domenico, Agnoli, Claudia, Tumino, Rosario, Vineis, Paolo, Panico, Salvatore, Quirã³s, J. Ramã³n, Sã¡nchez cantalejo, Emilio, Huerta, Josã© Marãa, Ardanaz, Eva, Arriola, Larraitz, Agudo, Antonio, Nilsson, Jan, Melander, Olle, Bueno de mesquita, Ba, Peeters, Petra H., Wareham, Nick, Khaw, Kay tee, Jenab, Mazda, Key, Timothy J., Scalbert, Augustin, Rinaldi, Sabina |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male obesity Chemistry(all) Metabolite Physiology Gene Expression Bioinformatics Biochemistry chemistry.chemical_compound 0302 clinical medicine Risk Factors Longitudinal Studies Amino Acids Liver Neoplasms Chemistry (all) Blood Proteins Middle Aged European Prospective Investigation into Cancer and Nutrition Sphingomyelins Europe targeted metabolome Cohort Metabolome Phosphatidylcholines Adult Biogenic Amines 030209 endocrinology & metabolism body mass index Biology Article 03 medical and health sciences Metabolomics blood Diabetes mellitus Carnitine medicine Journal Article Diabetes Mellitus Humans Hexoses Carcinoma Case-control study metabolic profiling General Chemistry medicine.disease 030104 developmental biology Nutrition Assessment chemistry Bile Duct Neoplasms Case-Control Studies Linear Models Body mass index |
| Zdroj: | Carayol, M, Leitzmann, M F, Ferrari, P, Zamora-Ros, R, Achaintre, D, Stepien, M, Schmidt, J A, Travis, R C, Overvad, K, Tjønneland, A, Hansen, L, Kaaks, R, Kühn, T, Boeing, H, Bachlechner, U, Trichopoulou, A, Bamia, C, Palli, D, Agnoli, C, Tumino, R, Vineis, P, Panico, S, Quirós, J R, Sánchez-Cantalejo, E, Huerta, J M, Ardanaz, E, Arriola, L, Agudo, A, Nilsson, J-A, Melander, O, Bueno-de-Mesquita, B, Peeters, P H, Wareham, N, Khaw, K-T, Jenab, M, Key, T J, Scalbert, A & Rinaldi, S 2017, ' Blood metabolic signatures of body mass index : a targeted metabolomics study in the EPIC cohort ', Journal of Proteome Research, vol. 16, no. 9, pp. 3137-3146 . https://doi.org/10.1021/acs.jproteome.6b01062 Journal of Proteome Research, 16(9), 3137. American Chemical Society |
| ISSN: | 1535-3893 |
| Popis: | OBJECTIVE: Metabolomic is now widely used to characterize metabolic phenotypes associated with lifestyle risk factors such as obesity. The objective of the present study was to explore the associations of body mass index (BMI) with 145 metabolites measured in blood samples in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.METHODS: Metabolites were measured in blood from 392 men from the Oxford (UK) cohort (EPIC-Oxford) and in 327 control subjects who were part of a nested case-control study on hepatobiliary carcinomas (EPIC-Hepatobiliary). Measured metabolites included amino acids, acylcarnitines, hexoses, biogenic amines, phosphatidylcholines, and sphingomyelins. Linear regression models controlled for potential confounders and multiple testing were run to evaluate the associations of metabolite concentrations with BMI.RESULTS: Forty and 45 individual metabolites showed significant differences according to BMI variations, in the EPIC-Oxford and EPIC-Hepatobiliary sub-cohorts, respectively. Twenty two individual metabolites were associated with BMI in both sub-cohorts including kynurenine, one sphingomyelin, glutamate and 19 phosphatidylcholines.CONCLUSIONS: The present findings provide additional knowledge on blood metabolic signatures of BMI in European adults, which may help identifying mechanisms mediating the relationship of BMI with obesity-related diseases. |
| Databáze: | OpenAIRE |
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