Wegener's granulomatosis presenting as multiple bilateral renal masses: case report and literature review
| Autor: | M. Frigui, Rachid Jlidi, Mohamed Ben Hmida, Zouhir Bahloul, Kechaou Ms |
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| Rok vydání: | 2008 |
| Předmět: |
Vasculitis
Pathology medicine.medical_specialty Biopsy Immunology urologic and male genital diseases Eye Kidney Antibodies Antineutrophil Cytoplasmic Diagnosis Differential Necrosis Rheumatology medicine Immunology and Allergy Humans Kidney surgery Fibrinoid necrosis Carcinoma Renal Cell Anti-neutrophil cytoplasmic antibody medicine.diagnostic_test business.industry Granulomatosis with Polyangiitis Middle Aged medicine.disease Radiography medicine.anatomical_structure Inflammatory pseudotumor Female Renal biopsy Differential diagnosis business |
| Zdroj: | Rheumatology international. 29(6) |
| ISSN: | 1437-160X |
| Popis: | Wegener’s granulomatosis (WG) is a disease of unknown etiology characterized by necrotizing granulomatous vascularitis. The upper and lower respiratory tract and kidney involvements are very common; however, its presentation as bilateral renal masses is unusual. We report a case of a 59-year-old female patient who presented with multiple bilateral renal masses. The patient presented with sinusal and ocular symptoms suggestive of WG, and positive antineutrophil cytoplasmic antibodies (c-ANCA) with an anti-PR3 pattern. Histopathologic examination of the renal biopsy specimen revealed granulomatous inflammation with vasculitis and fibrinoid necrosis. The patient management, including prednisone and cyclophosphamid, induced a marked improvement of the renal masses. This case illustrates that WG should be considered in the differential diagnosis of renal masses. |
| Databáze: | OpenAIRE |
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