Heneicosapentaenoate (21:5n-3): its incorporation into lipids and its effects on arachidonic acid and eicosanoid synthesis
| Autor: | F. Myhren, Kjerstin E. Høvik, Jon Bremer, K. H. Holm, Laila N. Larsen, B. Børretzen |
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| Rok vydání: | 1997 |
| Předmět: |
Fatty Acid Desaturases
Male endocrine system Docosahexaenoic Acids Thromboxane Biochemistry Linoleoyl-CoA Desaturase Substrate Specificity chemistry.chemical_compound Mice Delta-5 Fatty Acid Desaturase Liver Neoplasms Experimental Fatty Acids Omega-3 Animals Platelet health care economics and organizations Phospholipids Triglycerides chemistry.chemical_classification Oxidase test Arachidonate 5-Lipoxygenase Arachidonic Acid Organic Chemistry Fatty acid Cell Biology Lipid Metabolism Eicosapentaenoic acid Rats Eicosanoid chemistry Eicosapentaenoic Acid Liver Docosahexaenoic acid Prostaglandin-Endoperoxide Synthases Macrophages Peritoneal Eicosanoids lipids (amino acids peptides and proteins) Arachidonic acid hormones hormone substitutes and hormone antagonists |
| Zdroj: | Lipids. 32(7) |
| ISSN: | 0024-4201 |
| Popis: | 6,9,12,15,18-Heneicosapentaenoic acid (21:5n-3) (HPA), present in small amounts in fish oils, has been prepared by chemical elongation of eicosapentaenoic acid (EPA) and its biological properties compared with EPA and docosahexaenoic acid (DHA). All the double bonds of HPA are displaced one carbon away from the carboxyl group when compared to EPA. HPA is incorporated into phospholipids and into triacylglycerol in cell culture to a similar extent as EPA and DHA. HPA is a stronger inhibitor of the conversion of alpha-linoleic acid and dihomo-gamma-linolenic acid to arachidonic acid (AA) in hepatoma cells than are EPA, DHA, and AA. HPA is a poor substrate for prostaglandin H synthase and for 5-lipoxygenase, but it inactivates prostaglandin H synthase as rapidly as do AA, EPA, and DHA. HPA inhibits thromboxane synthesis in isolated platelets as efficiently as EPA. EPA, HPA, and DHA are all weak inducers of acyl-CoA oxidase in hepatoma cells. Therefore, since fish oils contain only small amounts of HPA, it is unlikely that this fatty acid is of particular significance for the biological effects of these oils, possibly with the exception that it is a strong inhibitor of AA synthesis. |
| Databáze: | OpenAIRE |
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