Surgery for large primary liver cancer more than 10�cm in diameter
| Autor: | Jia Fan, Bo-Heng Zhang, Zhao-You Tang, Xin-Da Zhou, Zhi-Quan Wu, Zeng-Chen Ma, Lun-Xiu Qin |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Liver Cirrhosis Male Curative resection Cancer Research medicine.medical_specialty Carcinoma Hepatocellular Adolescent Portal vein Gastroenterology Resection Risk Factors Internal medicine medicine Hepatectomy Humans Child Aged Retrospective Studies Aged 80 and over Hepatitis Hepatitis B Surface Antigens business.industry Liver Neoplasms Operative mortality General Medicine Middle Aged Prognosis medicine.disease Survival Analysis Surgery Clinical Practice Treatment Outcome Oncology Clinicopathological features Female business Primary liver cancer |
| Zdroj: | Journal of Cancer Research and Clinical Oncology. 129:543-548 |
| ISSN: | 1432-1335 0171-5216 |
| DOI: | 10.1007/s00432-003-0446-6 |
| Popis: | Large primary liver cancer (PLC) more than 10 cm in diameter is not infrequently encountered in clinical practice. This study evaluated the clinicopathological features and long-term results after surgery for large PLC.Comparison of clinicopathological data between patients with PLC/=10 cm ( n=1,227) and PLC10 cm ( n=2,349) during the same period.In comparison with patients with PLC10 cm, patients with PLC/=10 cm were significantly younger ( P0.01), had a lower incidence of asymptomatic tumors (9.1% vs 39.5%, P0.001), higher alpha-fetoprotein levels (400 ng/ml, 78.3% vs 49.2%, P0.001), higher gamma-glutamyl transpeptidase levels (6U, 87.7% vs 70.5%, P0.001), a lower incidence of a history of hepatitis (45.0% vs 61.4%, P0.001) and associated macronodular cirrhosis (cirrhotic nodules/=0.3 cm, 59.8% vs 66.6%, P0.001), poor differentiation of tumor cells (Edmondson grade 3-4, 24.3% vs 19.7%, P0.01), a lower percentage of single nodule tumors (59.9% vs 75.4%, P0.001) and well-encapsulated tumors (28.5% vs 62.1%, P0.001), a higher proportion of tumor emboli in the portal vein (20.5% vs 9.0%, P0.001), a lower resection rate (50.6% vs 86.8%, P0.001), a lower curative resection rate (54.8% vs 78.3%, P0.001), a higher operative mortality rate (4.5% vs 2.3%, P0.001), and less local resection (52.5% vs 80.2%, P0.001). The 5- and 10-year survival rates after resection were 26.2% and 17.5%, respectively, for patients with PLC/=10 cm ( n=621), and 54.3% and 39.5%, respectively, for patients with PLC10 cm ( n=2039) ( P0.01).Large PLC had specific clinicopathological features. Surgery is the first choice of treatment. In selected patients, resection is safe and offers the chance of long-term survival. Large PLC does not exclude the possibility of cure. |
| Databáze: | OpenAIRE |
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