Local projections of layer Vb-to-Va are more prominent in lateral than in medial entorhinal cortex
| Autor: | Menno P. Witter, Eirik S. Nilssen, Maximiliano José Nigro, Shinya Ohara, Rajeevkumar Raveendran Nair, Stefan Blankvoort, Clifford Kentros |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine Mouse QH301-705.5 Science Hippocampus Mice Transgenic Hippocampal formation local circuit systems memory consolidation General Biochemistry Genetics and Molecular Biology Mice 03 medical and health sciences 0302 clinical medicine parahippocampal region Medial entorhinal cortex medicine Animals Entorhinal Cortex Layer (object-oriented design) Biology (General) Memory Consolidation Neurons Neocortex General Immunology and Microbiology Chemistry General Neuroscience General Medicine hippocampal-entorhinal re-entry circuit Entorhinal cortex hippocampal-cortical output circuit 030104 developmental biology medicine.anatomical_structure Potential difference Medicine Female Memory consolidation Neuroscience 030217 neurology & neurosurgery Research Article |
| Zdroj: | eLife, Vol 10 (2021) eLIFE eLife |
| Popis: | The entorhinal cortex, in particular neurons in layer V, allegedly mediate transfer of information from the hippocampus to the neocortex, underlying long-term memory. Recently, this circuit has been shown to comprise a hippocampal output recipient layer Vb and a cortical projecting layer Va. With the use of in vitro electrophysiology in transgenic mice specific for layer Vb, we assessed the presence of the thus necessary connection from layer Vb-to-Va in the functionally distinct medial (MEC) and lateral (LEC) subdivisions; MEC, particularly its dorsal part, processes allocentric spatial information, whereas the corresponding part of LEC processes information representing elements of episodes. Using identical experimental approaches, we show that connections from layer Vb-to-Va neurons are stronger in dorsal LEC compared with dorsal MEC, suggesting different operating principles in these two regions. Although further in vivo experiments are needed, our findings imply a potential difference in how LEC and MEC mediate episodic systems consolidation. |
| Databáze: | OpenAIRE |
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