Dose dependent pharmacokinetics of prednisolone
| Autor: | W. W. Downie, J. R. Lowe, Valerie M. Rhind, M. E. Pickup, Verna Wright, Patricia A. Leatham |
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| Rok vydání: | 1977 |
| Předmět: |
Adult
Male medicine.medical_specialty Prednisolone medicine.medical_treatment Pharmacology Models Biological Steroid Pharmacokinetics Internal medicine medicine Humans Pharmacology (medical) Aged Volume of distribution Plasma clearance Dose-Response Relationship Drug business.industry Dose dependent pharmacokinetics Half-life General Medicine Middle Aged Blood proteins Kinetics Endocrinology Injections Intravenous Prednisone Female business medicine.drug |
| Zdroj: | European Journal of Clinical Pharmacology. 12:213-219 |
| ISSN: | 1432-1041 0031-6970 |
| DOI: | 10.1007/bf00609864 |
| Popis: | The pharmacokinetics of prednisolone elimination have been studied in both arthritic patients and normal volunteers using tritiated prednisolone alone, and in conjunction with unlabelled prednisolone in doses of 0.15 mg-kg-1 and 0.3 mg-kg-1 body weight. With increasing dose there is prolongation of the plasma half-life and increase in the volume of distribution and plasma clearance of prednisolone. It is proposed that these changes in pharmacokinetic parameters may be associated with non-linear binding of the steroid to plasma proteins. |
| Databáze: | OpenAIRE |
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