55P0110, a Novel Synthetic Compound Developed from a Plant Derived Backbone Structure, Shows Promising Anti-Hyperglycaemic Activity in Mice
| Autor: | Clemens Fürnsinn, Zsuzsanna Lehner, Klaus Frobel, Anton Luger, Immanuel Adorjan, Leonhardt Bauer, Karin Stadlbauer, B. Brunmair, Thomas Scherer |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty medicine.drug_class Dipeptidyl Peptidase 4 medicine.medical_treatment Administration Oral Mice Obese Blood sugar lcsh:Medicine Diabetes Mellitus Experimental Mice Internal medicine Diabetes mellitus medicine Animals Hypoglycemic Agents Insulin Gliclazide lcsh:Science Dipeptidyl peptidase-4 Glucose tolerance test Multidisciplinary medicine.diagnostic_test business.industry lcsh:R Glucose Tolerance Test medicine.disease Sulfonylurea Mice Inbred C57BL Endocrinology ROC Curve Basal (medicine) Area Under Curve lcsh:Q business Quinolizines Research Article medicine.drug |
| Zdroj: | PLoS ONE, Vol 10, Iss 5, p e0126847 (2015) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | Starting off with a structure derived from the natural compound multiflorine, a derivatisation program aimed at the discovery and initial characterisation of novel compounds with antidiabetic potential. Design and discovery of the structures was guided by oral bioactivities obtained in oral glucose tolerance tests in mice. 55P0110, one among several new compounds with distinct anti-hyperglycaemic activity, was further examined to characterise its pharmacology and mode of action. Whereas a single oral dose of 55P0110 did not affect basal glycaemia, it markedly improved the glucose tolerance of healthy and diabetic mice (peak blood glucose in glucose tolerance test, mmol/l: healthy mice with 90 mg/kg 55P0110, 17.0 ± 1.2 vs. 10.1 ± 1.1; diabetic mice with 180 mg/kg 55P0110, 23.1 ± 0.9 vs. 11.1 ± 1.4; p |
| Databáze: | OpenAIRE |
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