Ovarian cancer stem cell-specific gene expression profiling and targeted drug prescreening
| Autor: | Yuting Huang, Huiting Xiao, Wenxin Liu, Hu Yu, Quan Hao, Jing Tian, Zhi Yao, Baohui Ju, Xiangyu Liu, Feng-Hua Liu |
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| Rok vydání: | 2014 |
| Předmět: |
Ovarian Neoplasms
Regulation of gene expression Cancer Research Gene Expression Profiling Antineoplastic Agents General Medicine Biology medicine.disease_cause Gene Expression Regulation Neoplastic Gene expression profiling Oncology ErbB Cancer stem cell Neoplastic Stem Cells Cancer research medicine Humans Female Drug Screening Assays Antitumor KEGG Kinase activity Stem cell Transcriptome Carcinogenesis |
| Zdroj: | Oncology Reports. 31:1235-1248 |
| ISSN: | 1791-2431 1021-335X |
| DOI: | 10.3892/or.2014.2976 |
| Popis: | Cancer stem cells, with unlimited self-renewal potential and other stem cell characteristics, occur in several types of cancer, including ovarian cancer (OvC). Although CSCs can cause tumor initiation, malignant proliferation, relapse and multi-drug resistance, ways to eliminate them remain unknown. In the present study, we compared ovarian cancer stem cell (OVCSC) expression profiles in normal ovarian surface epithelium and ovarian cells from patients with advanced disease to identify key pathways and specific molecular signatures involved in OVC progression and to prescreen candidate small-molecule compounds with anti-OVCSC activity. Comparison of genome-wide expression profiles of OvC stemness groups with non-stemness controls revealed 6495, 1347 and 509 differentially expressed genes in SDC, SP1 and SP2 groups, respectively, with a cut-off of fold-change set at >1.5 and P |
| Databáze: | OpenAIRE |
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