Dereplication of Natural Products with Antimicrobial and Anticancer Activity from Brazilian Cyanobacteria

Autor: Lars Herfindal, Matti Wahlsten, Marli Fátima Fiore, Rafael Vicentini Popin, David P. Fewer, Kaarina Sivonen, Jouni Jokela, Tania Keiko Shishido
Přispěvatelé: Institute of Biotechnology, Department of Microbiology, Department of Food and Nutrition, Cyanobacteria research, Helsinki Institute of Sustainability Science (HELSUS), Microbial Natural Products
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0106 biological sciences
Cyanobacteria
Antifungal Agents
natural products
Health
Toxicology and Mutagenesis
Microorganism
nostoc
DIVERSITY
lcsh:Medicine
Toxicology
01 natural sciences
Anti-Infective Agents
Drug Discovery
MARINE CYANOBACTERIA
Gene Regulatory Networks
Nostoc
mass spectrometry
11832 Microbiology and virology
0303 health sciences
biology
Drug discovery
MOLECULAR-MECHANISMS
leukemia
Antimicrobial
Anti-Bacterial Agents
3. Good health
APOPTOSIS
Leukemia
Myeloid
Acute
Molecular network
Biochemistry
Brazil
Antifungal
COMPARATIVE GENOMICS
medicine.drug_class
Antineoplastic Agents
CELL-LINES
Microbial Sensitivity Tests
Photosynthesis
010603 evolutionary biology
Article
03 medical and health sciences
cyanotoxins
Cell Line
Tumor
medicine
Humans
CYCLIC PEPTIDE
030304 developmental biology
Biological Products
lcsh:R
MASS-SPECTROMETRY
biology.organism_classification
antibacterial
PROTEASE INHIBITORS
GEN. NOV
Drug Screening Assays
Antitumor
antifungal
Zdroj: Toxins
Volume 12
Issue 1
Toxins, Vol 12, Iss 1, p 12 (2019)
Popis: Cyanobacteria are photosynthetic organisms that produce a large diversity of natural products with interesting bioactivities for biotechnological and pharmaceutical applications. Cyanobacterial extracts exhibit toxicity towards other microorganisms and cancer cells and, therefore, represent a source of potentially novel natural products for drug discovery. We tested 62 cyanobacterial strains isolated from various Brazilian biomes for antileukemic and antimicrobial activities. Extracts from 39 strains induced selective apoptosis in acute myeloid leukemia (AML) cancer cell lines. Five of these extracts also exhibited antifungal and antibacterial activities. Chemical and dereplication analyses revealed the production of nine known natural products. Natural products possibly responsible for the observed bioactivities and five unknown, chemically related chlorinated compounds present only in Brazilian cyanobacteria were illustrated in a molecular network. Our results provide new information on the vast biosynthetic potential of cyanobacteria isolated from Brazilian environments.
Databáze: OpenAIRE
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