A Latent Class Analysis of Risk Factors for Acquiring HIV Among Men Who Have Sex with Men: Implications for Implementing Pre-Exposure Prophylaxis Programs
| Autor: | Philip A. Chan, Leandro Mena, Justine Maher, Catherine E. Oldenburg, Mickey Lally, Stacey Benben, Joanna Poceta, Kristen Pfeiffer, Brandon D.L. Marshall, Alexi Almonte, Amy Nunn, Kenneth H. Mayer, Rupa R. Patel, Jennifer S. Rose, Sharon Parker |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Program evaluation medicine.medical_specialty Adolescent Urban Population Anti-HIV Agents media_common.quotation_subject Population Sexually Transmitted Diseases Human immunodeficiency virus (HIV) HIV Infections medicine.disease_cause Men who have sex with men Young Adult Pre-exposure prophylaxis Risk-Taking Risk Factors Prevalence medicine Humans Homosexuality Homosexuality Male Young adult education media_common Gynecology education.field_of_study business.industry Clinical and Epidemiologic Research Public Health Environmental and Occupational Health Rhode Island virus diseases Middle Aged Latent class model Sexual Partners Infectious Diseases Pre-Exposure Prophylaxis business Program Evaluation Demography |
| Zdroj: | AIDS Patient Care and STDs. 29:597-605 |
| ISSN: | 1557-7449 1087-2914 |
| DOI: | 10.1089/apc.2015.0113 |
| Popis: | Current Centers for Disease Control and Prevention (CDC) guidelines for prescribing pre-exposure prophylaxis (PrEP) to prevent HIV transmission are broad. In order to better characterize groups who may benefit most from PrEP, we reviewed demographics, behaviors, and clinical outcomes for individuals presenting to a publicly-funded sexually transmitted diseases (STD) clinic in Providence, Rhode Island, from 2012 to 2014. Latent class analysis (LCA) was used to identify subgroups of men who have sex with men (MSM) at highest risk for contracting HIV. A total of 1723 individuals presented for testing (75% male; 31% MSM). MSM were more likely to test HIV positive than heterosexual men or women. Among 538 MSM, we identified four latent classes. Class 1 had the highest rates of incarceration (33%), forced sex (24%), but had no HIV infections. Class 2 had 10 anal sex partners in the previous 12 months (69%), anonymous partners (100%), drug/alcohol use during sex (76%), and prior STDs (40%). Class 4 had similar characteristics and HIV prevalence as Class 2. In this population, MSM who may benefit most from PrEP include those who have >10 sexual partners per year, anonymous partners, drug/alcohol use during sex and prior STDs. LCA is a useful tool for identifying clusters of characteristics that may place individuals at higher risk for HIV infection and who may benefit most from PrEP in clinical practice. |
| Databáze: | OpenAIRE |
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