Involvement of Mossy Cells in Sharp Wave-Ripple Activity In Vitro
| Autor: | Dietmar Schmitz, Aarti Swaminathan, Ines Wichert, Nikolaus Maier |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
physiology [Excitatory Postsynaptic Potentials] Time Factors hippocampus Population Action Potentials Biology Hippocampal formation physiology [Mossy Fibers Hippocampal] Inhibitory postsynaptic potential behavioral disciplines and activities General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Mice 0302 clinical medicine physiology [Action Potentials] Biological neural network mossy cell Hippocampus (mythology) physiology [Inhibitory Postsynaptic Potentials] Animals hilus dentate gyrus ddc:610 education lcsh:QH301-705.5 education.field_of_study learning Dentate gyrus Excitatory Postsynaptic Potentials CA3 Region Hippocampal humanities In vitro physiology [CA3 Region Hippocampal] 030104 developmental biology lcsh:Biology (General) Inhibitory Postsynaptic Potentials Mossy Fibers Hippocampal Excitatory postsynaptic potential Neuroscience 030217 neurology & neurosurgery sharp wave-ripple complex |
| Zdroj: | Cell reports 23(9), 2541-2549 (2018). doi:10.1016/j.celrep.2018.04.095 Cell Reports, Vol 23, Iss 9, Pp 2541-2549 (2018) |
| ISSN: | 2211-1247 |
| DOI: | 10.1016/j.celrep.2018.04.095 |
| Popis: | The role of mossy cells (MCs) of the hippocampal dentate area has long remained mysterious. Recent research has begun to unveil their significance in spatial computation of the hippocampus. Here, we used an in vitro model of sharp wave-ripple complexes (SWRs), which contribute to hippocampal memory formation, to investigate MC involvement in this fundamental population activity. We find that a significant fraction of MCs (∼47%) is recruited into the active neuronal network during SWRs in the CA3 area. Moreover, MCs receive pronounced, ripple-coherent, excitatory and inhibitory synaptic input. Finally, we find evidence for SWR-related synaptic activity in granule cells that is mediated by MCs. Given the widespread connectivity of MCs within and between hippocampi, our data suggest a role for MCs as a hub functionally coupling the CA3 and the DG during ripple-associated computations. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|