Patterns of Multi-Antibiotic-Resistant Escherichia Coli from Streams with No History of Antimicrobial Inputs
Autor: | J. V. McArthur, Dean E. Fletcher, R. Cary Tuckfield, Craig Baker-Austin |
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Rok vydání: | 2015 |
Předmět: |
0301 basic medicine
Geologic Sediments medicine.drug_class Microorganism 030106 microbiology Antibiotics Soil Science Microbial Sensitivity Tests Biology beta-Lactams medicine.disease_cause Gatifloxacin beta-Lactam Resistance Microbiology 03 medical and health sciences Antibiotic resistance Rivers Microbial ecology Ciprofloxacin Drug Resistance Multiple Bacterial Escherichia coli medicine Ecology Evolution Behavior and Systematics Ecology Antimicrobial Anti-Bacterial Agents Drug Combinations Aminoglycosides Water Microbiology Fluoroquinolones medicine.drug |
Zdroj: | Microbial Ecology. 72:840-850 |
ISSN: | 1432-184X 0095-3628 |
Popis: | A growing body of evidence suggests that contaminated environments may harbor a greater proportion of antibiotic-resistant microorganisms than unpolluted reference sites. Here, we report the screening of 427 Escherichia coli strains isolated from 11 locations on nine streams draining the US Department of Energy’s Savannah River Site against a panel of five antibiotics. Streams were chosen to capture a wide range of watersheds from minimally disturbed to highly impacted. Overall, higher levels of resistance were found in waterborne E. coli that also generally exhibited low spatial variability. However, 3 of 11 locations also demonstrated elevated resistance levels in sediments. Two of these occurred in highly disturbed tributaries with no obvious sources of antimicrobials. To further investigate these patterns, we screened a subset of isolates obtained from three streams against 23 antibiotics or antibiotic combinations. A large proportion of these isolates (>40 %) demonstrated resistance to 10 or more antimicrobials, suggesting that environmental multi-antibiotic resistance may be prevalent in this bacterial commensal. Only 4 of 87 viable isolates were tested susceptible to all 23 antibiotics and combinations. Among these multi-antibiotic-resistant isolates, several demonstrated resistance to all structural classes of antimicrobial agents tested, including frontline antibiotics such as gatifloxacin and ciprofloxacin. |
Databáze: | OpenAIRE |
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