Patterns of Recurrence After Salvage Radiotherapy Encompassing Pelvic Lymphatics in Men with High-risk Prostate Cancer
| Autor: | Young Seok Kim, Minji Koh, Hanjong Ahn, Choung-Soo Kim |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty medicine.medical_treatment Anastomosis Prostate cancer Medicine Humans Lymph node Pelvis Aged Prostatectomy Salvage Therapy business.industry Prostatic Neoplasms General Medicine Middle Aged medicine.disease Radiation therapy medicine.anatomical_structure Lymphatic system Treatment Outcome Oncology Salvage radiotherapy Radiotherapy Adjuvant Radiology Lymph Nodes Radiotherapy Intensity-Modulated Neoplasm Recurrence Local business |
| Zdroj: | Anticancer research. 38(11) |
| ISSN: | 1791-7530 |
| Popis: | Background/aim The efficacy of adjuvant or salvage radiation to the regional lymph node area has not been fully investigated in high-risk prostate cancer patients; instead, radiotherapy is limited to the prostate fossa. The present study aimed to assess patterns of recurrence in prostate cancer patients with biochemical failure (BCF) who were treated with whole-pelvic salvage radiotherapy (SRT) following radical prostatectomy. Patients and methods The clinical data from 196 high-risk prostate cancer patients who received SRT for BCF after radical prostatectomy were reviewed. BCF after SRT was detected in 80 patients, and 59 patients underwent imaging studies. Results Twenty four recurrences in 16 patients were identified, including 13 bone metastases, 6 vesicourethral anastomosis site recurrences, and 5 lymph node recurrences (one simultaneous with vesicourethral anastomosis). Regarding the treatment field, no in-field nodal recurrence was observed, whereas 4 out-of-field and 1 edge-of-field recurrences were detected. Conclusion Locoregional recurrence was most common at the anastomosis site. Most nodal recurrences were located outside the pelvis, suggesting that elective pelvic nodal irradiation should be recommended in a selected patient population. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|