Characterization of Immunoregulatory T Cells in EBV-Induced Infectious Mononucleosis by Monoclonal Antibodies
| Autor: | De Waele M, Van Camp Bk, Thielemans C |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Adult
Cytotoxicity Immunologic Male Adolescent Mononucleosis medicine.drug_class T-Lymphocytes Receptors Antigen B-Cell Disease Monoclonal antibody T-Lymphocytes Regulatory Antibodies Virus Antigen medicine Humans Cytotoxic T cell Infectious Mononucleosis Functional studies biology Histocompatibility Antigens Class II General Medicine medicine.disease Virology Antigens Surface Immunology biology.protein Female Antibody |
| Zdroj: | New England Journal of Medicine. 304:460-462 |
| ISSN: | 1533-4406 0028-4793 |
| DOI: | 10.1056/nejm198102193040804 |
| Popis: | IN infectious mononucleosis induced by Epstein–Barr virus (EBV), an initial viral infection of B lymphocytes1 is usually followed by an extensive proliferation of T cells.2 , 3 In functional studies these T cells are cytotoxic against EBV-infected lymphoid cells4 , 5 and inhibit their outgrowth.6 In addition, they suppress autologous T-cell proliferation to antigens as well as B-cell immunoglobulin production stimulated by pokeweed mitogen.7 , 8 They are thought to be of major importance in the self-limiting aspect of the disease. Maturation and differentiation of T-lymphoid cells into lymphocyte subsets with particular immunologic functions is expressed by distinctive patterns of cell-surface antigens.9 Recently, monoclonal antibodies directed . . . |
| Databáze: | OpenAIRE |
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